Impact of aberrant myeloid antigen expression on outcomes of patients with t-cell acute lymphoblastic leukemia
المؤلفون المشاركون
Fawwaz, Najla
al-Hunayni, Muhammad
al-Kindi, Salam
al-Lamki, Sulaymah
al-Zabi, Muhammad
al-Muslahi, Muhanna
al-Khaburi, Murtada
al-Riyami, Arwa
المصدر
العدد
المجلد 32، العدد 3 (31 مايو/أيار 2017)، ص ص. 189-193، 5ص.
الناشر
المجلس العماني للاختصاصات الطبية
تاريخ النشر
2017-05-31
دولة النشر
سلطنة عمان
عدد الصفحات
5
التخصصات الرئيسية
الملخص EN
Objectives: To evaluate the impact of myeloid antigen expression on complete remission (CR), event-free survival (EFS), and overall survival (OS) in patients with T-cell acute lymphoblastic leukemia (T-ALL) treated with intensive chemotherapy.
Methods: We retrospectively reviewed consecutive patients diagnosed with T-ALL and treated in Sultan Qaboos University Hospital and Royal Hospital in Oman between 2004 and 2010.
The diagnosis of T-ALL was established using French-American-British classification or World Health Organization criteria.
Patients were considered having myeloid antigen expression if they expressed CD13, CD33, or both (My+ and My–).
Results: Of the 39 patients, 38 were included in the study (25 patients with My– and median age of 18.4 years, 13 patients with My+ and median age of 22.0 years).
Median follow-up was 12 months.
Thirty-two out of the total cohort were eligible for response-rate assessment.
Twenty-nine patients (90.6%) achieved CR with one or two courses of chemotherapy with similar CR rates between the two groups (p = 0.880).
Twenty-five percent (5/20) of the patients with My– required two courses of induction, whereas 58.3% (7/12) of My+ required two courses of induction and the difference was statistically significant (p = 0.040).
In the multivariable analysis; age, gender, initial white blood cell count, central nervous system disease, and myeloid antigen expression were not statistically significant predictors of CR.
The EFS and OS were similar between the My+ and My– groups p = 0.180 and p = 0.440, respectively.
Conclusions: Patients with T-ALL with myeloid antigen expression need more courses of induction; however, rates of CR, EFS, and OS are not different from those without myeloid antigen expression.
Larger prospective studies are required to confirm these findings
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
al-Zabi, Muhammad& al-Khaburi, Murtada& Fawwaz, Najla& al-Lamki, Sulaymah& al-Riyami, Arwa& al-Muslahi, Muhanna…[et al.]. 2017. Impact of aberrant myeloid antigen expression on outcomes of patients with t-cell acute lymphoblastic leukemia. Oman Medical Journal،Vol. 32, no. 3, pp.189-193.
https://search.emarefa.net/detail/BIM-772331
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
al-Muslahi, Muhanna…[et al.]. Impact of aberrant myeloid antigen expression on outcomes of patients with t-cell acute lymphoblastic leukemia. Oman Medical Journal Vol. 32, no. 3 (May. 2017), pp.189-193.
https://search.emarefa.net/detail/BIM-772331
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
al-Zabi, Muhammad& al-Khaburi, Murtada& Fawwaz, Najla& al-Lamki, Sulaymah& al-Riyami, Arwa& al-Muslahi, Muhanna…[et al.]. Impact of aberrant myeloid antigen expression on outcomes of patients with t-cell acute lymphoblastic leukemia. Oman Medical Journal. 2017. Vol. 32, no. 3, pp.189-193.
https://search.emarefa.net/detail/BIM-772331
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 192-193
رقم السجل
BIM-772331
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر