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Impact of aberrant myeloid antigen expression on outcomes of patients with t-cell acute lymphoblastic leukemia
Joint Authors
Fawwaz, Najla
al-Hunayni, Muhammad
al-Kindi, Salam
al-Lamki, Sulaymah
al-Zabi, Muhammad
al-Muslahi, Muhanna
al-Khaburi, Murtada
al-Riyami, Arwa
Source
Issue
Vol. 32, Issue 3 (31 May. 2017), pp.189-193, 5 p.
Publisher
Publication Date
2017-05-31
Country of Publication
Oman
No. of Pages
5
Main Subjects
Abstract EN
Objectives: To evaluate the impact of myeloid antigen expression on complete remission (CR), event-free survival (EFS), and overall survival (OS) in patients with T-cell acute lymphoblastic leukemia (T-ALL) treated with intensive chemotherapy.
Methods: We retrospectively reviewed consecutive patients diagnosed with T-ALL and treated in Sultan Qaboos University Hospital and Royal Hospital in Oman between 2004 and 2010.
The diagnosis of T-ALL was established using French-American-British classification or World Health Organization criteria.
Patients were considered having myeloid antigen expression if they expressed CD13, CD33, or both (My+ and My–).
Results: Of the 39 patients, 38 were included in the study (25 patients with My– and median age of 18.4 years, 13 patients with My+ and median age of 22.0 years).
Median follow-up was 12 months.
Thirty-two out of the total cohort were eligible for response-rate assessment.
Twenty-nine patients (90.6%) achieved CR with one or two courses of chemotherapy with similar CR rates between the two groups (p = 0.880).
Twenty-five percent (5/20) of the patients with My– required two courses of induction, whereas 58.3% (7/12) of My+ required two courses of induction and the difference was statistically significant (p = 0.040).
In the multivariable analysis; age, gender, initial white blood cell count, central nervous system disease, and myeloid antigen expression were not statistically significant predictors of CR.
The EFS and OS were similar between the My+ and My– groups p = 0.180 and p = 0.440, respectively.
Conclusions: Patients with T-ALL with myeloid antigen expression need more courses of induction; however, rates of CR, EFS, and OS are not different from those without myeloid antigen expression.
Larger prospective studies are required to confirm these findings
American Psychological Association (APA)
al-Zabi, Muhammad& al-Khaburi, Murtada& Fawwaz, Najla& al-Lamki, Sulaymah& al-Riyami, Arwa& al-Muslahi, Muhanna…[et al.]. 2017. Impact of aberrant myeloid antigen expression on outcomes of patients with t-cell acute lymphoblastic leukemia. Oman Medical Journal،Vol. 32, no. 3, pp.189-193.
https://search.emarefa.net/detail/BIM-772331
Modern Language Association (MLA)
al-Muslahi, Muhanna…[et al.]. Impact of aberrant myeloid antigen expression on outcomes of patients with t-cell acute lymphoblastic leukemia. Oman Medical Journal Vol. 32, no. 3 (May. 2017), pp.189-193.
https://search.emarefa.net/detail/BIM-772331
American Medical Association (AMA)
al-Zabi, Muhammad& al-Khaburi, Murtada& Fawwaz, Najla& al-Lamki, Sulaymah& al-Riyami, Arwa& al-Muslahi, Muhanna…[et al.]. Impact of aberrant myeloid antigen expression on outcomes of patients with t-cell acute lymphoblastic leukemia. Oman Medical Journal. 2017. Vol. 32, no. 3, pp.189-193.
https://search.emarefa.net/detail/BIM-772331
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 192-193
Record ID
BIM-772331