Association of FTO rs9939609 SNP with obesity and obesity : associated phenotypes in a north Indian population
المؤلفون المشاركون
Mittal, Balraj
Srivastava, Apurva
Awasthi, Shally
Srivastava, Neena
Prakash, Jai
المصدر
العدد
المجلد 31، العدد 2 (31 مارس/آذار 2016)، ص ص. 99-106، 8ص.
الناشر
المجلس العماني للاختصاصات الطبية
تاريخ النشر
2016-03-31
دولة النشر
سلطنة عمان
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Objectives : Obesity is a common disorder that has a significant impact on morbidity and mortality.
Twin and adoption studies support the genetic influence on variation of obesity, and the estimates of the heritability of body mass index (BMI) is significantly high (30 to 70%).
Variants in the fat mass and obesity-associated (FTO) gene have been associated with obesity and obesity-related phenotypes in different populations.
The aim of this study was to examine the association of FTO rs9939609 with obesity and related phenotypes in North Indian subjects.
Methods: Gene variants were investigated for association with obesity in 309 obese and 333 non-obese patients.
Genotyping of the FTO rs9939609 single nucleotide polymorphism (SNP) was analyzed using Restriction Fragment Length Polymorphism Analysis of PCR-Amplified Fragments.
We also measured participants fasting glucose and insulin levels, lipid profile, percentage body fat, fat mass and fat free mass.
Results: Waist to hip ratio, systolic blood pressure, diastolic blood pressure, percentage body fat, fat mass, insulin concentration, and homeostasis model assessment index (HOMA-Index) showed a significant difference between the study groups.
Significant associations were found for FTO rs9939609 SNP with obesity and obesity-related phenotypes.
The significant associations were observed between the rs9939609 SNP and blood pressure, fat mass, insulin, and HOMA-index under a different model.
Conclusion: This study presents significant association between FTO rs9939609 and obesity defined by BMI and also established the strong association with several measures of obesity in North Indian population.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Prakash, Jai& Mittal, Balraj& Srivastava, Apurva& Awasthi, Shally& Srivastava, Neena. 2016. Association of FTO rs9939609 SNP with obesity and obesity : associated phenotypes in a north Indian population. Oman Medical Journal،Vol. 31, no. 2, pp.99-106.
https://search.emarefa.net/detail/BIM-772656
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Prakash, Jai…[et al.]. Association of FTO rs9939609 SNP with obesity and obesity : associated phenotypes in a north Indian population. Oman Medical Journal Vol. 31, no. 2 (Mar. 2016), pp.99-106.
https://search.emarefa.net/detail/BIM-772656
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Prakash, Jai& Mittal, Balraj& Srivastava, Apurva& Awasthi, Shally& Srivastava, Neena. Association of FTO rs9939609 SNP with obesity and obesity : associated phenotypes in a north Indian population. Oman Medical Journal. 2016. Vol. 31, no. 2, pp.99-106.
https://search.emarefa.net/detail/BIM-772656
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 104-105
رقم السجل
BIM-772656
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر