Promoter polymorphism (590, T C)‎ of interleukin 4 (IL4)‎ gene is associated with rheumatoid arthritis : an updated meta-analysis

الملخص EN

Rheumatoid arthritis (RA) is a chronic disease.

It causes chronic inflammation of the joint.

Recent studies suggested that interleukin 4 (IL4) contributes to susceptibility and severity of rheumatoid arthritis (RA).

Especially, it was reported that promoter polymorphism (590, T/C) of IL4 gene has been associated with susceptibility of RA.

The aim of present study was to investigate whether the promoter polymorphism (590, T/C) of IL4 gene is associated with the susceptibility of RA using metaanalysis.

And in order to perform meta-analysis, comprehensive meta analysis program was used.

Genetic models (co-dominant, dominant, recessive, and allele) were used to determine odds ratios (ORs), 95% confidence intervals (CIs), and P values.

Nine case-control studies with case and control design were included in thismeta-analysis.Overall,meta-analysis revealed a strong associationwith susceptibility of RA [OR=1.303, 95% CI=1.093–1.554, P=0.003 in allele model (C vs.

T); OR= 1.247, 95% CI=1.054–1.474, P=0.010 in dominant model (CC vs.

CT+TT); OR= 2.148, 95% CI=1.263–3.651, P=0.005 in recessive model (CC+CT vs.

TT)].

Our data demonstrated that promoter polymorphism (590, T/C) of IL4 gene may be contributed to susceptibility ofRA.

However, more studies with a larger sample size are needed to provide more precise evidence.