Promoter polymorphism (590, T C) of interleukin 4 (IL4) gene is associated with rheumatoid arthritis : an updated meta-analysis
Joint Authors
Arasu, Mariadhas Valan
Park, Hyun Kyung
Kim, Su Kang
Kweon, Hae Yong
Lee, Kwan Gill
Kim, Young Ock
Source
Saudi Journal of Biological Sciences
Issue
Vol. 24, Issue 2 (28 Feb. 2017), pp.444-449, 6 p.
Publisher
Publication Date
2017-02-28
Country of Publication
Saudi Arabia
No. of Pages
6
Main Subjects
Topics
Abstract EN
Rheumatoid arthritis (RA) is a chronic disease.
It causes chronic inflammation of the joint.
Recent studies suggested that interleukin 4 (IL4) contributes to susceptibility and severity of rheumatoid arthritis (RA).
Especially, it was reported that promoter polymorphism (590, T/C) of IL4 gene has been associated with susceptibility of RA.
The aim of present study was to investigate whether the promoter polymorphism (590, T/C) of IL4 gene is associated with the susceptibility of RA using metaanalysis.
And in order to perform meta-analysis, comprehensive meta analysis program was used.
Genetic models (co-dominant, dominant, recessive, and allele) were used to determine odds ratios (ORs), 95% confidence intervals (CIs), and P values.
Nine case-control studies with case and control design were included in thismeta-analysis.Overall,meta-analysis revealed a strong associationwith susceptibility of RA [OR=1.303, 95% CI=1.093–1.554, P=0.003 in allele model (C vs.
T); OR= 1.247, 95% CI=1.054–1.474, P=0.010 in dominant model (CC vs.
CT+TT); OR= 2.148, 95% CI=1.263–3.651, P=0.005 in recessive model (CC+CT vs.
TT)].
Our data demonstrated that promoter polymorphism (590, T/C) of IL4 gene may be contributed to susceptibility ofRA.
However, more studies with a larger sample size are needed to provide more precise evidence.
American Psychological Association (APA)
Park, Hyun Kyung& Kim, Su Kang& Kweon, Hae Yong& Lee, Kwan Gill& Arasu, Mariadhas Valan& Kim, Young Ock. 2017. Promoter polymorphism (590, T C) of interleukin 4 (IL4) gene is associated with rheumatoid arthritis : an updated meta-analysis. Saudi Journal of Biological Sciences،Vol. 24, no. 2, pp.444-449.
https://search.emarefa.net/detail/BIM-776451
Modern Language Association (MLA)
Park, Hyun Kyung…[et al.]. Promoter polymorphism (590, T C) of interleukin 4 (IL4) gene is associated with rheumatoid arthritis : an updated meta-analysis. Saudi Journal of Biological Sciences Vol. 24, no. 2 (Feb. 2017), pp.444-449.
https://search.emarefa.net/detail/BIM-776451
American Medical Association (AMA)
Park, Hyun Kyung& Kim, Su Kang& Kweon, Hae Yong& Lee, Kwan Gill& Arasu, Mariadhas Valan& Kim, Young Ock. Promoter polymorphism (590, T C) of interleukin 4 (IL4) gene is associated with rheumatoid arthritis : an updated meta-analysis. Saudi Journal of Biological Sciences. 2017. Vol. 24, no. 2, pp.444-449.
https://search.emarefa.net/detail/BIM-776451
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 448-449
Record ID
BIM-776451