The hepatoprotective effects of vitamin C and micronized vitamin c against paracetamol induced hepatotoxicity in rats : a comparative study
المؤلفون المشاركون
Hasanayn, K. M. A.
Hashim, K. S.
المصدر
Beni-Suef Veterinary Medical Journal
العدد
المجلد 22، العدد 1(s) (30 يونيو/حزيران 2013)، ص ص. 46-52، 7ص.
الناشر
جامعة بني سويف كلية الطب البيطري
تاريخ النشر
2013-06-30
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Micronization of chemical compounds is a new promising field as it reduces the size of the particles thus it increases their penetration power.
Many theories prove that micronized particles are more effective even in very low concentration as compared to its normal size.
Paracetamol is a commonly used effective analgesic and antipyretic agent for relief of mild and moderate pain.
However, deliberate overdose or accidental overdose can cause hepatotoxicity.
In the present study, we have evaluated and compared between the hepatoprotective and antioxidant effects of vitamin C and micronized vitamin C against paracetamol induced hepatotoxicity in rats.
Activities of liver enzymatic markers (Alanine amino transferase "ALT", Aspartate amino transferase "AST", Alkaline Phosphatase "ALP") and total protein "TP" concentration were estimated in serum.
Lipid peroxidation "MDA" and antioxidant status (reduced glutathione "GSH" concentration, glutathione reductase "GR", catalse and super oxide dismutase "SOD" activities) were measured in tissue homogenates.
Paracetamol administration (600 mg/ Kg B.wt.) significantly increased the liver enzymatic markers and decreased the total protein level.
It also increased hepatic lipid peroxidation “MDA” and the activities of both catalase and SOD while it decreased GSH content and glutathione reductase (GR) activity.
Treatment of vitamin C and micronized vtamin C restore the measured parameters nearly to their normal levels.
Finally, micronized vitamin C has a more potent effect than ordinary vitamin C.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Hasanayn, K. M. A.& Hashim, K. S.. 2013. The hepatoprotective effects of vitamin C and micronized vitamin c against paracetamol induced hepatotoxicity in rats : a comparative study. Beni-Suef Veterinary Medical Journal،Vol. 22, no. 1(s), pp.46-52.
https://search.emarefa.net/detail/BIM-778679
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Hasanayn, K. M. A.& Hashim, K. S.. The hepatoprotective effects of vitamin C and micronized vitamin c against paracetamol induced hepatotoxicity in rats : a comparative study. Beni-Suef Veterinary Medical Journal Vol. 22, no. 1(s) (2013), pp.46-52.
https://search.emarefa.net/detail/BIM-778679
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Hasanayn, K. M. A.& Hashim, K. S.. The hepatoprotective effects of vitamin C and micronized vitamin c against paracetamol induced hepatotoxicity in rats : a comparative study. Beni-Suef Veterinary Medical Journal. 2013. Vol. 22, no. 1(s), pp.46-52.
https://search.emarefa.net/detail/BIM-778679
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 51-52
رقم السجل
BIM-778679
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر