The hepatoprotective effects of vitamin C and micronized vitamin c against paracetamol induced hepatotoxicity in rats : a comparative study
Joint Authors
Hasanayn, K. M. A.
Hashim, K. S.
Source
Beni-Suef Veterinary Medical Journal
Issue
Vol. 22, Issue 1(s) (30 Jun. 2013), pp.46-52, 7 p.
Publisher
Beni-Suef University Faculty of Veterinary Medicine
Publication Date
2013-06-30
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Micronization of chemical compounds is a new promising field as it reduces the size of the particles thus it increases their penetration power.
Many theories prove that micronized particles are more effective even in very low concentration as compared to its normal size.
Paracetamol is a commonly used effective analgesic and antipyretic agent for relief of mild and moderate pain.
However, deliberate overdose or accidental overdose can cause hepatotoxicity.
In the present study, we have evaluated and compared between the hepatoprotective and antioxidant effects of vitamin C and micronized vitamin C against paracetamol induced hepatotoxicity in rats.
Activities of liver enzymatic markers (Alanine amino transferase "ALT", Aspartate amino transferase "AST", Alkaline Phosphatase "ALP") and total protein "TP" concentration were estimated in serum.
Lipid peroxidation "MDA" and antioxidant status (reduced glutathione "GSH" concentration, glutathione reductase "GR", catalse and super oxide dismutase "SOD" activities) were measured in tissue homogenates.
Paracetamol administration (600 mg/ Kg B.wt.) significantly increased the liver enzymatic markers and decreased the total protein level.
It also increased hepatic lipid peroxidation “MDA” and the activities of both catalase and SOD while it decreased GSH content and glutathione reductase (GR) activity.
Treatment of vitamin C and micronized vtamin C restore the measured parameters nearly to their normal levels.
Finally, micronized vitamin C has a more potent effect than ordinary vitamin C.
American Psychological Association (APA)
Hasanayn, K. M. A.& Hashim, K. S.. 2013. The hepatoprotective effects of vitamin C and micronized vitamin c against paracetamol induced hepatotoxicity in rats : a comparative study. Beni-Suef Veterinary Medical Journal،Vol. 22, no. 1(s), pp.46-52.
https://search.emarefa.net/detail/BIM-778679
Modern Language Association (MLA)
Hasanayn, K. M. A.& Hashim, K. S.. The hepatoprotective effects of vitamin C and micronized vitamin c against paracetamol induced hepatotoxicity in rats : a comparative study. Beni-Suef Veterinary Medical Journal Vol. 22, no. 1(s) (2013), pp.46-52.
https://search.emarefa.net/detail/BIM-778679
American Medical Association (AMA)
Hasanayn, K. M. A.& Hashim, K. S.. The hepatoprotective effects of vitamin C and micronized vitamin c against paracetamol induced hepatotoxicity in rats : a comparative study. Beni-Suef Veterinary Medical Journal. 2013. Vol. 22, no. 1(s), pp.46-52.
https://search.emarefa.net/detail/BIM-778679
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 51-52
Record ID
BIM-778679