Anti-inflammatory and analgesic activity of ononitol monohydrate isolated from Cassia tora L. in animal models

الملخص EN

Ononitol monohydrate (OM) was isolated from Cassia tora L.

leaves.

The anti-inflammatory and analgesic activities of OM have been examined in male Wistar rats and mice.

The efficacy of OM against inflammation was studied by using carrageenan-induced paw oedema, croton oil-induced ear oedema, acetic acidinduced vascular permeability, cotton pellet-induced granuloma and adjuvant-induced arthritis.

The analgesic activity of OM was assessed using the acetic acid-induced abdominal constriction response, formalin-induced paw licking response and the hot-plate test.

In acute type inflammation models, maximum inhibitions of 50.69 and 61.06% (P < .05) were noted with 20 mg/kg of OM in carrageenan-induced hind paw oedema and croton oil-induced ear oedema, respectively.

Treatment of OM (20 mg / kg) meaningfully (P < .05) reduced the granuloma tissue formation by cotton pellet study at a rate of 36.25 %.

OM (20 mg / kg) inhibited 53.64 % of paw thickness in adjuvant-induced arthritis model.

OM has also been produced significant (P < .05) analgesic activity in acetic acid-induced abdominal constriction response, formalin-induced paw licking response and in hot-plate test suggesting its peripheral and central analgesic potential.

The outcomes of the present study proposed that OM influenced on the anti-inflammatory and analgesic activities.