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Anti-inflammatory and analgesic activity of ononitol monohydrate isolated from Cassia tora L. in animal models
Joint Authors
Antonisamy, Paulrayer
Dhanasekaran, Muniyappan
Kim, Ha Rim
Jo, Sung Gang
Agastian, Paul
Kwon, Kang Beom
Source
Saudi Journal of Biological Sciences
Issue
Vol. 24, Issue 8 (31 Dec. 2017), pp.1933-1938, 6 p.
Publisher
Publication Date
2017-12-31
Country of Publication
Saudi Arabia
No. of Pages
6
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Abstract EN
Ononitol monohydrate (OM) was isolated from Cassia tora L.
leaves.
The anti-inflammatory and analgesic activities of OM have been examined in male Wistar rats and mice.
The efficacy of OM against inflammation was studied by using carrageenan-induced paw oedema, croton oil-induced ear oedema, acetic acidinduced vascular permeability, cotton pellet-induced granuloma and adjuvant-induced arthritis.
The analgesic activity of OM was assessed using the acetic acid-induced abdominal constriction response, formalin-induced paw licking response and the hot-plate test.
In acute type inflammation models, maximum inhibitions of 50.69 and 61.06% (P < .05) were noted with 20 mg/kg of OM in carrageenan-induced hind paw oedema and croton oil-induced ear oedema, respectively.
Treatment of OM (20 mg / kg) meaningfully (P < .05) reduced the granuloma tissue formation by cotton pellet study at a rate of 36.25 %.
OM (20 mg / kg) inhibited 53.64 % of paw thickness in adjuvant-induced arthritis model.
OM has also been produced significant (P < .05) analgesic activity in acetic acid-induced abdominal constriction response, formalin-induced paw licking response and in hot-plate test suggesting its peripheral and central analgesic potential.
The outcomes of the present study proposed that OM influenced on the anti-inflammatory and analgesic activities.
American Psychological Association (APA)
Antonisamy, Paulrayer& Dhanasekaran, Muniyappan& Kim, Ha Rim& Jo, Sung Gang& Agastian, Paul& Kwon, Kang Beom. 2017. Anti-inflammatory and analgesic activity of ononitol monohydrate isolated from Cassia tora L. in animal models. Saudi Journal of Biological Sciences،Vol. 24, no. 8, pp.1933-1938.
https://search.emarefa.net/detail/BIM-780622
Modern Language Association (MLA)
Antonisamy, Paulrayer…[et al.]. Anti-inflammatory and analgesic activity of ononitol monohydrate isolated from Cassia tora L. in animal models. Saudi Journal of Biological Sciences Vol. 24, no. 8 (Dec. 2017), pp.1933-1938.
https://search.emarefa.net/detail/BIM-780622
American Medical Association (AMA)
Antonisamy, Paulrayer& Dhanasekaran, Muniyappan& Kim, Ha Rim& Jo, Sung Gang& Agastian, Paul& Kwon, Kang Beom. Anti-inflammatory and analgesic activity of ononitol monohydrate isolated from Cassia tora L. in animal models. Saudi Journal of Biological Sciences. 2017. Vol. 24, no. 8, pp.1933-1938.
https://search.emarefa.net/detail/BIM-780622
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 1937-1938
Record ID
BIM-780622