Structural alterations in rat myocardium induced by chronic L-arginine and L-Name supplementation
المؤلفون المشاركون
Korac, Aleksandra
Markelic, Milica
Hamid, Amal Abd al-Salam Ali A.
Masovic, Sava
Otasevic, Vesna
Jankovic, Aleksandra
Korac, Bato
المصدر
Saudi Journal of Biological Sciences
العدد
المجلد 25، العدد 3 (31 مارس/آذار 2018)، ص ص. 537-544، 8ص.
الناشر
تاريخ النشر
2018-03-31
دولة النشر
السعودية
عدد الصفحات
8
التخصصات الرئيسية
الموضوعات
الملخص EN
Structural changes affecting cardiomyocyte function may contribute to the athophysiological remodeling underlying cardiac function impairment.
Recent reports have shown that endogenous nitric oxide (NO) plays an important role in this process.
In order to examine the role of NO in cardiomyocyte remodeling, male rats were acclimated to room temperature (22± 1 °C) or cold (4 ± 1 °C) and treated with 2.25 % L-arginineHCl or 0.01 % L-Name (Nx-nitro-L-arginine methyl ester)HCl for 45 days.
Untreated groups served as controls.
Right heart ventricles were routinely prepared for light microscopic examination.
Stereological estimations of volume densities of cardiomyocytes, surrounding blood vessels and connective tissue, as well as the morphometric measurements of cardiomyocyte diameters were performed.
Tissue sections were also analyzed for structural alterations.
We observed that both L-arginine and L-Name supplementation induced cardiomyocyte hypertrophy, regardless of ambient temperature.
However, cardiomyocyte hypertrophy was associated with fibrosis and extra collagen deposition only in the L-Name treated group.
Taken together, our results suggest that NO has a modulatory role in right heart ventricle remodeling by coordinating hypertrophy of cardiomyocytes and fibrous tissue preventing cardiac fibrosis.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Hamid, Amal Abd al-Salam Ali A.& Markelic, Milica& Otasevic, Vesna& Masovic, Sava& Jankovic, Aleksandra& Korac, Bato…[et al.]. 2018. Structural alterations in rat myocardium induced by chronic L-arginine and L-Name supplementation. Saudi Journal of Biological Sciences،Vol. 25, no. 3, pp.537-544.
https://search.emarefa.net/detail/BIM-780667
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Hamid, Amal Abd al-Salam Ali A.…[et al.]. Structural alterations in rat myocardium induced by chronic L-arginine and L-Name supplementation. Saudi Journal of Biological Sciences Vol. 25, no. 3 (Mar. 2018), pp.537-544.
https://search.emarefa.net/detail/BIM-780667
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Hamid, Amal Abd al-Salam Ali A.& Markelic, Milica& Otasevic, Vesna& Masovic, Sava& Jankovic, Aleksandra& Korac, Bato…[et al.]. Structural alterations in rat myocardium induced by chronic L-arginine and L-Name supplementation. Saudi Journal of Biological Sciences. 2018. Vol. 25, no. 3, pp.537-544.
https://search.emarefa.net/detail/BIM-780667
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 542-544
رقم السجل
BIM-780667
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر