Structural alterations in rat myocardium induced by chronic L-arginine and L-Name supplementation
Joint Authors
Korac, Aleksandra
Markelic, Milica
Hamid, Amal Abd al-Salam Ali A.
Masovic, Sava
Otasevic, Vesna
Jankovic, Aleksandra
Korac, Bato
Source
Saudi Journal of Biological Sciences
Issue
Vol. 25, Issue 3 (31 Mar. 2018), pp.537-544, 8 p.
Publisher
Publication Date
2018-03-31
Country of Publication
Saudi Arabia
No. of Pages
8
Main Subjects
Topics
Abstract EN
Structural changes affecting cardiomyocyte function may contribute to the athophysiological remodeling underlying cardiac function impairment.
Recent reports have shown that endogenous nitric oxide (NO) plays an important role in this process.
In order to examine the role of NO in cardiomyocyte remodeling, male rats were acclimated to room temperature (22± 1 °C) or cold (4 ± 1 °C) and treated with 2.25 % L-arginineHCl or 0.01 % L-Name (Nx-nitro-L-arginine methyl ester)HCl for 45 days.
Untreated groups served as controls.
Right heart ventricles were routinely prepared for light microscopic examination.
Stereological estimations of volume densities of cardiomyocytes, surrounding blood vessels and connective tissue, as well as the morphometric measurements of cardiomyocyte diameters were performed.
Tissue sections were also analyzed for structural alterations.
We observed that both L-arginine and L-Name supplementation induced cardiomyocyte hypertrophy, regardless of ambient temperature.
However, cardiomyocyte hypertrophy was associated with fibrosis and extra collagen deposition only in the L-Name treated group.
Taken together, our results suggest that NO has a modulatory role in right heart ventricle remodeling by coordinating hypertrophy of cardiomyocytes and fibrous tissue preventing cardiac fibrosis.
American Psychological Association (APA)
Hamid, Amal Abd al-Salam Ali A.& Markelic, Milica& Otasevic, Vesna& Masovic, Sava& Jankovic, Aleksandra& Korac, Bato…[et al.]. 2018. Structural alterations in rat myocardium induced by chronic L-arginine and L-Name supplementation. Saudi Journal of Biological Sciences،Vol. 25, no. 3, pp.537-544.
https://search.emarefa.net/detail/BIM-780667
Modern Language Association (MLA)
Hamid, Amal Abd al-Salam Ali A.…[et al.]. Structural alterations in rat myocardium induced by chronic L-arginine and L-Name supplementation. Saudi Journal of Biological Sciences Vol. 25, no. 3 (Mar. 2018), pp.537-544.
https://search.emarefa.net/detail/BIM-780667
American Medical Association (AMA)
Hamid, Amal Abd al-Salam Ali A.& Markelic, Milica& Otasevic, Vesna& Masovic, Sava& Jankovic, Aleksandra& Korac, Bato…[et al.]. Structural alterations in rat myocardium induced by chronic L-arginine and L-Name supplementation. Saudi Journal of Biological Sciences. 2018. Vol. 25, no. 3, pp.537-544.
https://search.emarefa.net/detail/BIM-780667
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 542-544
Record ID
BIM-780667