Potential role of cyanidin 3-glucoside (C3G) in diabetic cardiomyopathy in diabetic rats : an in vivo approach
المؤلفون المشاركون
Li, Weizhen
Chen, Songwen
Zhou, Genqing
Zhong, Lan
Liu, Shaowen
Li, Hongli
المصدر
Saudi Journal of Biological Sciences
العدد
المجلد 25، العدد 3 (31 مارس/آذار 2018)، ص ص. 500-506، 7ص.
الناشر
تاريخ النشر
2018-03-31
دولة النشر
السعودية
عدد الصفحات
7
التخصصات الرئيسية
الموضوعات
الملخص EN
The present study aimed to evaluate the importance of cyanidin 3-glucoside (C3G) of diabetic cardiomyopathy in diabetic rats.
The rats were induced with diabetic using streptozotocin and total triglyceride (TG) and total cholesterol (TC) were determined.
The range of myocardial enzymes such as aspartate aminotransferase (AST), creatine kinase (CK) and lactate dehydrogenase)LD) were also estimated, further, the Immuno histochemical analysis and western blot investigation were determined for the actual activity of C3G.
Results indicated that the marker enzymes such as CK, LD and AST were significantly (P <0.05) increased in STZ administered rats (DM group), while the levels of these elevated marker enzymes of cardiac injury significantly (P < 0.05) declined in the DM + C3G group, as compared to the diabetic group of rats.
Additionally, a decrease in the level of TNF-alpha and interleukin-6, was noticed in the C3G treated group as compared to diabetic group.
Finally, blotting analysis clearly confirmed that theC3G treatment resulted to higher level response of Bcl-2 and lower level response of caspase-3 and BAX.
In conclusion, C3G a natural antioxidant may prevent cardiovascular complications by ameliorating oxidative damage, inflammation, metabolic dysfunctions and apoptosis pathways in type 2 diabetes.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Li, Weizhen& Chen, Songwen& Zhou, Genqing& Li, Hongli& Zhong, Lan& Liu, Shaowen. 2018. Potential role of cyanidin 3-glucoside (C3G) in diabetic cardiomyopathy in diabetic rats : an in vivo approach. Saudi Journal of Biological Sciences،Vol. 25, no. 3, pp.500-506.
https://search.emarefa.net/detail/BIM-780692
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Li, Weizhen…[et al.]. Potential role of cyanidin 3-glucoside (C3G) in diabetic cardiomyopathy in diabetic rats : an in vivo approach. Saudi Journal of Biological Sciences Vol. 25, no. 3 (Mar. 2018), pp.500-506.
https://search.emarefa.net/detail/BIM-780692
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Li, Weizhen& Chen, Songwen& Zhou, Genqing& Li, Hongli& Zhong, Lan& Liu, Shaowen. Potential role of cyanidin 3-glucoside (C3G) in diabetic cardiomyopathy in diabetic rats : an in vivo approach. Saudi Journal of Biological Sciences. 2018. Vol. 25, no. 3, pp.500-506.
https://search.emarefa.net/detail/BIM-780692
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 505-506
رقم السجل
BIM-780692
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر