Potential role of cyanidin 3-glucoside (C3G) in diabetic cardiomyopathy in diabetic rats : an in vivo approach
Joint Authors
Li, Weizhen
Chen, Songwen
Zhou, Genqing
Zhong, Lan
Liu, Shaowen
Li, Hongli
Source
Saudi Journal of Biological Sciences
Issue
Vol. 25, Issue 3 (31 Mar. 2018), pp.500-506, 7 p.
Publisher
Publication Date
2018-03-31
Country of Publication
Saudi Arabia
No. of Pages
7
Main Subjects
Topics
Abstract EN
The present study aimed to evaluate the importance of cyanidin 3-glucoside (C3G) of diabetic cardiomyopathy in diabetic rats.
The rats were induced with diabetic using streptozotocin and total triglyceride (TG) and total cholesterol (TC) were determined.
The range of myocardial enzymes such as aspartate aminotransferase (AST), creatine kinase (CK) and lactate dehydrogenase)LD) were also estimated, further, the Immuno histochemical analysis and western blot investigation were determined for the actual activity of C3G.
Results indicated that the marker enzymes such as CK, LD and AST were significantly (P <0.05) increased in STZ administered rats (DM group), while the levels of these elevated marker enzymes of cardiac injury significantly (P < 0.05) declined in the DM + C3G group, as compared to the diabetic group of rats.
Additionally, a decrease in the level of TNF-alpha and interleukin-6, was noticed in the C3G treated group as compared to diabetic group.
Finally, blotting analysis clearly confirmed that theC3G treatment resulted to higher level response of Bcl-2 and lower level response of caspase-3 and BAX.
In conclusion, C3G a natural antioxidant may prevent cardiovascular complications by ameliorating oxidative damage, inflammation, metabolic dysfunctions and apoptosis pathways in type 2 diabetes.
American Psychological Association (APA)
Li, Weizhen& Chen, Songwen& Zhou, Genqing& Li, Hongli& Zhong, Lan& Liu, Shaowen. 2018. Potential role of cyanidin 3-glucoside (C3G) in diabetic cardiomyopathy in diabetic rats : an in vivo approach. Saudi Journal of Biological Sciences،Vol. 25, no. 3, pp.500-506.
https://search.emarefa.net/detail/BIM-780692
Modern Language Association (MLA)
Li, Weizhen…[et al.]. Potential role of cyanidin 3-glucoside (C3G) in diabetic cardiomyopathy in diabetic rats : an in vivo approach. Saudi Journal of Biological Sciences Vol. 25, no. 3 (Mar. 2018), pp.500-506.
https://search.emarefa.net/detail/BIM-780692
American Medical Association (AMA)
Li, Weizhen& Chen, Songwen& Zhou, Genqing& Li, Hongli& Zhong, Lan& Liu, Shaowen. Potential role of cyanidin 3-glucoside (C3G) in diabetic cardiomyopathy in diabetic rats : an in vivo approach. Saudi Journal of Biological Sciences. 2018. Vol. 25, no. 3, pp.500-506.
https://search.emarefa.net/detail/BIM-780692
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 505-506
Record ID
BIM-780692