Chemoprotective effect of omega-3 fatty acids on thioacetamide induced hepatic fibrosis in male rats
المؤلفون المشاركون
al-Rethia, Hayfa A.
al-Attar, Atif M.
المصدر
Saudi Journal of Biological Sciences
العدد
المجلد 24، العدد 4 (31 مايو/أيار 2017)، ص ص. 956-965، 10ص.
الناشر
تاريخ النشر
2017-05-31
دولة النشر
السعودية
عدد الصفحات
10
التخصصات الرئيسية
الموضوعات
الملخص EN
The current study was designed to investigate the possible protective effect of omega-3 fatty acids from fish oil on hepatic fibrosis induced by thioacetamide (TAA) in male rats.
The experimental animals were divided into four groups.
The first group was received saline solution and served as control.
The second group was given 250 mg/kg body weight of TAA.
The third group was treated with omega-3 fatty acids and TAA.
The fourth group was given saline solution and supplemented with omega-3 fatty acids.
Treatment of rats with TAA for three and six weeks resulted in a significant decrease in body weight gain, while the value of liver/body weight ratio was statistically increased.
Furthermore, the levels of serum alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase, gamma glutamyl transferase and total bilirubin were significantly increased.
After three weeks of exposure to only TAA, liver sections showed an abnormal morphology characterized by noticeable fibrosis with the extracellular matrix collagen contents and damage of liver cells’ structure.
Liver sections from rats treated with only TAA for six weeks revealed an obvious increase in extracellular matrix collagen content and bridging fibrosis.
Treating TAA-intoxicated rats with omega-3 fatty acids significantly attenuated the severe physiological and histopathological changes.
Finally, the present investigation suggests that omega-3 fatty acids could act against hepatic fibrosis induced by TAA due to its antioxidant properties, thus supporting its use in hepatic fibrosis therapy.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
al-Attar, Atif M.& al-Rethia, Hayfa A.. 2017. Chemoprotective effect of omega-3 fatty acids on thioacetamide induced hepatic fibrosis in male rats. Saudi Journal of Biological Sciences،Vol. 24, no. 4, pp.956-965.
https://search.emarefa.net/detail/BIM-782270
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
al-Attar, Atif M.& al-Rethia, Hayfa A.. Chemoprotective effect of omega-3 fatty acids on thioacetamide induced hepatic fibrosis in male rats. Saudi Journal of Biological Sciences Vol. 24, no. 4 (May. 2017), pp.956-965.
https://search.emarefa.net/detail/BIM-782270
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
al-Attar, Atif M.& al-Rethia, Hayfa A.. Chemoprotective effect of omega-3 fatty acids on thioacetamide induced hepatic fibrosis in male rats. Saudi Journal of Biological Sciences. 2017. Vol. 24, no. 4, pp.956-965.
https://search.emarefa.net/detail/BIM-782270
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 964-965
رقم السجل
BIM-782270
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر