Chemoprotective effect of omega-3 fatty acids on thioacetamide induced hepatic fibrosis in male rats
Joint Authors
al-Rethia, Hayfa A.
al-Attar, Atif M.
Source
Saudi Journal of Biological Sciences
Issue
Vol. 24, Issue 4 (31 May. 2017), pp.956-965, 10 p.
Publisher
Publication Date
2017-05-31
Country of Publication
Saudi Arabia
No. of Pages
10
Main Subjects
Topics
Abstract EN
The current study was designed to investigate the possible protective effect of omega-3 fatty acids from fish oil on hepatic fibrosis induced by thioacetamide (TAA) in male rats.
The experimental animals were divided into four groups.
The first group was received saline solution and served as control.
The second group was given 250 mg/kg body weight of TAA.
The third group was treated with omega-3 fatty acids and TAA.
The fourth group was given saline solution and supplemented with omega-3 fatty acids.
Treatment of rats with TAA for three and six weeks resulted in a significant decrease in body weight gain, while the value of liver/body weight ratio was statistically increased.
Furthermore, the levels of serum alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase, gamma glutamyl transferase and total bilirubin were significantly increased.
After three weeks of exposure to only TAA, liver sections showed an abnormal morphology characterized by noticeable fibrosis with the extracellular matrix collagen contents and damage of liver cells’ structure.
Liver sections from rats treated with only TAA for six weeks revealed an obvious increase in extracellular matrix collagen content and bridging fibrosis.
Treating TAA-intoxicated rats with omega-3 fatty acids significantly attenuated the severe physiological and histopathological changes.
Finally, the present investigation suggests that omega-3 fatty acids could act against hepatic fibrosis induced by TAA due to its antioxidant properties, thus supporting its use in hepatic fibrosis therapy.
American Psychological Association (APA)
al-Attar, Atif M.& al-Rethia, Hayfa A.. 2017. Chemoprotective effect of omega-3 fatty acids on thioacetamide induced hepatic fibrosis in male rats. Saudi Journal of Biological Sciences،Vol. 24, no. 4, pp.956-965.
https://search.emarefa.net/detail/BIM-782270
Modern Language Association (MLA)
al-Attar, Atif M.& al-Rethia, Hayfa A.. Chemoprotective effect of omega-3 fatty acids on thioacetamide induced hepatic fibrosis in male rats. Saudi Journal of Biological Sciences Vol. 24, no. 4 (May. 2017), pp.956-965.
https://search.emarefa.net/detail/BIM-782270
American Medical Association (AMA)
al-Attar, Atif M.& al-Rethia, Hayfa A.. Chemoprotective effect of omega-3 fatty acids on thioacetamide induced hepatic fibrosis in male rats. Saudi Journal of Biological Sciences. 2017. Vol. 24, no. 4, pp.956-965.
https://search.emarefa.net/detail/BIM-782270
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 964-965
Record ID
BIM-782270