Factors associated with relapse of lupus nephritis : a single center study of 249 cases
المؤلفون المشاركون
Hajji, Maryam
Hirz Allah, Amal
Kaaroud, Hayet
Bin Hamidah, Fathi
Barbush, Samiyah
Bin Abd Allah, Tayyib
المصدر
Saudi Journal of Kidney Diseases and Transplantation
العدد
المجلد 28، العدد 6 (31 ديسمبر/كانون الأول 2017)، ص ص. 1349-1355، 7ص.
الناشر
تاريخ النشر
2017-12-31
دولة النشر
السعودية
عدد الصفحات
7
التخصصات الرئيسية
الموضوعات
الملخص EN
This is a retrospective cohort study over 20 years (1990–2013) that included all patients with biopsy-proven lupus nephritis (LN) followed up at our nephrology department.
We aimed to determine the clinicobiologic predictors of flare-up of LN.
Flare was defined as an increase in systemic lupus erythematosus (SLE) disease activity index (SLEDAI) score of at least four points.
Clinical manifestations and laboratory parameters were assessed and the SLEDAI score was determined for each patient.
We included patients with SLE who fulfilled at least four of the American College of Rheumatology criteria for the classification of SLE.
A total of 249 patients including 227 females and 22 males with a median age at diagnosis of 34.32 years (range 16–69) were studied.
The mean follow-up duration was 122.4 ± 27 months.
Renal symptoms included hypertension in 40%, nephrotic syndrome in 30%, and renal failure in 69.4% of the cases.
Class IV and class III nephritis (ISN/RPS) were observed in 44.9% and 24% of the patients, respectively.
On univariate analysis, flare predictors were age <30 years (P = 0.02), lymphocytopenia (P = 0.002), the presence of diffuse proliferative LN (P = 0.009), and discontinuation of immunosuppressive therapy (P = 0.004).
Our study suggests that these markers should be monitored routinely as prognostic parameters in SLE to characterize patients who are at risk and who should be followed more closely
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Hajji, Maryam& Hirz Allah, Amal& Kaaroud, Hayet& Barbush, Samiyah& Bin Hamidah, Fathi& Bin Abd Allah, Tayyib. 2017. Factors associated with relapse of lupus nephritis : a single center study of 249 cases. Saudi Journal of Kidney Diseases and Transplantation،Vol. 28, no. 6, pp.1349-1355.
https://search.emarefa.net/detail/BIM-785656
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Hajji, Maryam…[et al.]. Factors associated with relapse of lupus nephritis : a single center study of 249 cases. Saudi Journal of Kidney Diseases and Transplantation Vol. 28, no. 6 (Nov. / Dec. 2017), pp.1349-1355.
https://search.emarefa.net/detail/BIM-785656
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Hajji, Maryam& Hirz Allah, Amal& Kaaroud, Hayet& Barbush, Samiyah& Bin Hamidah, Fathi& Bin Abd Allah, Tayyib. Factors associated with relapse of lupus nephritis : a single center study of 249 cases. Saudi Journal of Kidney Diseases and Transplantation. 2017. Vol. 28, no. 6, pp.1349-1355.
https://search.emarefa.net/detail/BIM-785656
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 1354-1355
رقم السجل
BIM-785656
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر