Factors associated with relapse of lupus nephritis : a single center study of 249 cases
Joint Authors
Hajji, Maryam
Hirz Allah, Amal
Kaaroud, Hayet
Bin Hamidah, Fathi
Barbush, Samiyah
Bin Abd Allah, Tayyib
Source
Saudi Journal of Kidney Diseases and Transplantation
Issue
Vol. 28, Issue 6 (31 Dec. 2017), pp.1349-1355, 7 p.
Publisher
Saudi Center for Organ Transplantation
Publication Date
2017-12-31
Country of Publication
Saudi Arabia
No. of Pages
7
Main Subjects
Topics
Abstract EN
This is a retrospective cohort study over 20 years (1990–2013) that included all patients with biopsy-proven lupus nephritis (LN) followed up at our nephrology department.
We aimed to determine the clinicobiologic predictors of flare-up of LN.
Flare was defined as an increase in systemic lupus erythematosus (SLE) disease activity index (SLEDAI) score of at least four points.
Clinical manifestations and laboratory parameters were assessed and the SLEDAI score was determined for each patient.
We included patients with SLE who fulfilled at least four of the American College of Rheumatology criteria for the classification of SLE.
A total of 249 patients including 227 females and 22 males with a median age at diagnosis of 34.32 years (range 16–69) were studied.
The mean follow-up duration was 122.4 ± 27 months.
Renal symptoms included hypertension in 40%, nephrotic syndrome in 30%, and renal failure in 69.4% of the cases.
Class IV and class III nephritis (ISN/RPS) were observed in 44.9% and 24% of the patients, respectively.
On univariate analysis, flare predictors were age <30 years (P = 0.02), lymphocytopenia (P = 0.002), the presence of diffuse proliferative LN (P = 0.009), and discontinuation of immunosuppressive therapy (P = 0.004).
Our study suggests that these markers should be monitored routinely as prognostic parameters in SLE to characterize patients who are at risk and who should be followed more closely
American Psychological Association (APA)
Hajji, Maryam& Hirz Allah, Amal& Kaaroud, Hayet& Barbush, Samiyah& Bin Hamidah, Fathi& Bin Abd Allah, Tayyib. 2017. Factors associated with relapse of lupus nephritis : a single center study of 249 cases. Saudi Journal of Kidney Diseases and Transplantation،Vol. 28, no. 6, pp.1349-1355.
https://search.emarefa.net/detail/BIM-785656
Modern Language Association (MLA)
Hajji, Maryam…[et al.]. Factors associated with relapse of lupus nephritis : a single center study of 249 cases. Saudi Journal of Kidney Diseases and Transplantation Vol. 28, no. 6 (Nov. / Dec. 2017), pp.1349-1355.
https://search.emarefa.net/detail/BIM-785656
American Medical Association (AMA)
Hajji, Maryam& Hirz Allah, Amal& Kaaroud, Hayet& Barbush, Samiyah& Bin Hamidah, Fathi& Bin Abd Allah, Tayyib. Factors associated with relapse of lupus nephritis : a single center study of 249 cases. Saudi Journal of Kidney Diseases and Transplantation. 2017. Vol. 28, no. 6, pp.1349-1355.
https://search.emarefa.net/detail/BIM-785656
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 1354-1355
Record ID
BIM-785656