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Does alpha-lipoic acid comsumption improve lipid profile in patients with stroke ? : a randomized, double blind, placebo-controlled clinical trial
المؤلفون المشاركون
Muhammadi, Vida
Khorvash, Fariborz
Askari, Ghulam Rida
Feizi, Awat
المصدر
Iranian Red Crescent Medical Journal
العدد
المجلد 19، العدد 8 (31 أغسطس/آب 2017)، ص ص. 1-6، 6ص.
الناشر
تاريخ النشر
2017-08-31
دولة النشر
الإمارات العربية المتحدة
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
Background : Having a stroke, which is a devastating condition, is a major cause of deaths worldwide and is also accountable for long time disability with high personal and social cost in adults.
Hyperlipidemia plays an important role in atherothrombosis, which is the precursor to stroke.
One way for decreasing the risk of a stroke is treatment of dyslipidemia.
Alpha-lipoic acid (ALA) is aneight-carbon, sulfur-containingcompoundwith antioxidant propertiesandeffective in protecting against hypercholesterolemia and hepatic fat accumulation.
Objectives : We designed this trial to scrutinize the possible effects of ALAconsumptiononlipid profiles in patientswhoexperienced a stroke.
Methods : In this randomized, double blind, placebo-controlled clinical trial, 67 patients who experienced a stroke were randomly allocated into 2 groups (taking a 600mgALA supplement or placebo daily for 12 weeks).
The triglyceride (TG), total cholesterol (TC), LDL-cholesterol (LDL), and HDL-cholesterol (HDL) were measured and LDL-cholesterol/ HDL-cholesterol (LDL/ HDL) as well as total cholesterol/ HDL-cholesterol (TC/ HDL) were calculated before and after intervention in this study.
Dietary intake and statistical analyses were carried out using the N4 and SPSS16 software, respectively.
Results : Primary features were similar in the intervention and placebo groups (P< 0.05).
After the intervention period, serum levels of TG (123.2149.63 vs.
152.9758.83) (P < 0.001), TC (148.6737.71 vs.
174.3536.86) (P < 0.001), and LDL (85.0923.81 vs.
107.56 31.73) (P = 0.002) decreased, and HDL level (589.33 vs.
42.97 8.07) (P < 0.001) increased significantly in ALA group compared with the placebo.
In addition, LDL/ HDL (P < 0.001) and TC/ HDL (P < 0.001) reduced significantly.
Conclusions : Results of this trial indicated that 12 weeks of supplementation with 600 mg alpha-lipoic acid has beneficial effects on lipid profile (TG, TC, LDL, HDL, LDL-/HDL, and TC/HDL) in patients who have experienced a stroke.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Muhammadi, Vida& Khorvash, Fariborz& Feizi, Awat& Askari, Ghulam Rida. 2017. Does alpha-lipoic acid comsumption improve lipid profile in patients with stroke ? : a randomized, double blind, placebo-controlled clinical trial. Iranian Red Crescent Medical Journal،Vol. 19, no. 8, pp.1-6.
https://search.emarefa.net/detail/BIM-789925
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Muhammadi, Vida…[et al.]. Does alpha-lipoic acid comsumption improve lipid profile in patients with stroke ? : a randomized, double blind, placebo-controlled clinical trial. Iranian Red Crescent Medical Journal Vol. 19, no. 8 (Aug. 2017), pp.1-6.
https://search.emarefa.net/detail/BIM-789925
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Muhammadi, Vida& Khorvash, Fariborz& Feizi, Awat& Askari, Ghulam Rida. Does alpha-lipoic acid comsumption improve lipid profile in patients with stroke ? : a randomized, double blind, placebo-controlled clinical trial. Iranian Red Crescent Medical Journal. 2017. Vol. 19, no. 8, pp.1-6.
https://search.emarefa.net/detail/BIM-789925
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 5-6
رقم السجل
BIM-789925
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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