Significant role of loss or reduced BRCA1 gene expression in clinical implication of ovarian cancer
المؤلفون المشاركون
al-Budayri, Furqan J.
al-Kashwan, Dhikra A.
al-Muzaffar, Rihab H.
المصدر
العدد
المجلد 17، العدد 1 (30 يونيو/حزيران 2014)، ص ص. 62-76، 15ص.
الناشر
تاريخ النشر
2014-06-30
دولة النشر
العراق
عدد الصفحات
15
التخصصات الرئيسية
الملخص EN
Background: BRCA1 immunohistochemistry (IHC) provides a rapid initial screen to detect BRCA1 dysfunction in ovarian cancer that resulting from genetic alterations.
Aim: To assess the expression of BRCA1 protein by IHC analysis among a group of Iraqi ovarian cancer patients to evaluate the patterns of expression and its correlation with the clinicopathological parameters in attempting to evaluate a significance role of BRCA1 gene implication in ovarian cancer.
Methods: Forty three paraffin embedded samples of ovarian cancer cases were analyzed for BRCA1dysfunction by IHC analysis.
The semi-quantitative approach using modified histochemical score (H-score) was achieved to assess the patterns of BRCA1 gene expression.
Results: Complete loss of BRCA1 nuclear expression was detected in 30.2% of the cases while, reduced expression occurred in 46.5% of cases, giving rise to 76.7% of all cases detected with altered BRCA1 nuclear expression.
Altered BRCA1 expression was found to be higher in age group ≤ 45 years (78.3%) in comparison with those of ages >45 years.
Altered BRCA1 expression was significantly correlated with the high grade and with the unilateral tumor site when compared with the low grade and bilateral tumor site (P≤0.05), and was insignificantly correlated with the high stage ovarian tumors, 11.6% of cases were detected by cytoplasmic BRCA1 expression and no association was found between cytoplasmic expression and tumor grade, stage and tumor site.
Conclusion: Altered BRCA1 expression may play a significant role in the progression of ovarian cancer.
Recommendation: BRCA1 IHC is a clinically useful approach to detect the BRCA1 dysfunction and the H-score assessment reflects good estimation for BRCA1expression patterns.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
al-Kashwan, Dhikra A.& al-Budayri, Furqan J.& al-Muzaffar, Rihab H.. 2014. Significant role of loss or reduced BRCA1 gene expression in clinical implication of ovarian cancer. Kufa Medical Journal،Vol. 17, no. 1, pp.62-76.
https://search.emarefa.net/detail/BIM-790716
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
al-Muzaffar, Rihab H.…[et al.]. Significant role of loss or reduced BRCA1 gene expression in clinical implication of ovarian cancer. Kufa Medical Journal Vol. 17, no. 1 (2014), pp.62-76.
https://search.emarefa.net/detail/BIM-790716
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
al-Kashwan, Dhikra A.& al-Budayri, Furqan J.& al-Muzaffar, Rihab H.. Significant role of loss or reduced BRCA1 gene expression in clinical implication of ovarian cancer. Kufa Medical Journal. 2014. Vol. 17, no. 1, pp.62-76.
https://search.emarefa.net/detail/BIM-790716
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 73-76
رقم السجل
BIM-790716
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر