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In vivo time-dependent radio-protective effect of lycopene against whole-body gamma radiation in mice
المؤلفون المشاركون
Oladi, Muhammad Rida
Sazgarnia, Aminah
Nasiri, Muhammad Rida Ghavam
Amrollahi, Mustafa
Parhiz, Hamidah
Ramezani, Muhammad
المصدر
Iranian Red Crescent Medical Journal
العدد
المجلد 19، العدد 2 (28 فبراير/شباط 2017)، ص ص. 1-8، 8ص.
الناشر
تاريخ النشر
2017-02-28
دولة النشر
الإمارات العربية المتحدة
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Background: Ionizing radiation has become an essential part of modern medicine.
However, applying the effective dose of ionizing radiation is compromised by its inevitable radiation-induced damage to normal tissues.
Natural products with free radical scavenging, antioxidant activities, and immune stimulatory effects offer suitable radio-protective effects.
Objectives: This study was designed to evaluate the in vivo radio-protective activity of lycopene, a naturally dietary carotenoid, against whole-body gamma-irradiation-induced mortality and sickness in mice.
Methods: In this animal experimental study, lycopene was extracted from tomato paste, characterized, and then administered to mice.
Consecutively, 80 healthy adult male mice were recruited and irradiated individually, and then monitored for irradiation sickness and survival parameters.
Results: Pretreatment with 7 mg/kg dose of lycopene 7 days before irradiation was found to reduce the severity of symptoms of radiation sickness in a 30-day post-radiation monitoring.
Lycopene treatment increased the survival rate.
At the radiation dosage of 8 and 9 Gy, the difference between the survival rates of control and sample groups became significant after day 15 and 25.
Lycopene was also shown to have a protective effect on white blood cell count against 8 and 9 Gy gamma radiations.
Conclusions: Natural and exhibitingwhole-body radio-protective activity, lycopene can be proposed as an effective radio-protector in healthy people who are exposed to radiation, such as radiographers, nuclear pharmacists, and radiologists.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Oladi, Muhammad Rida& Sazgarnia, Aminah& Nasiri, Muhammad Rida Ghavam& Amrollahi, Mustafa& Parhiz, Hamidah& Ramezani, Muhammad. 2017. In vivo time-dependent radio-protective effect of lycopene against whole-body gamma radiation in mice. Iranian Red Crescent Medical Journal،Vol. 19, no. 2, pp.1-8.
https://search.emarefa.net/detail/BIM-791805
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Oladi, Muhammad Rida…[et al.]. In vivo time-dependent radio-protective effect of lycopene against whole-body gamma radiation in mice. Iranian Red Crescent Medical Journal Vol. 19, no. 2 (Feb. 2017), pp.1-8.
https://search.emarefa.net/detail/BIM-791805
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Oladi, Muhammad Rida& Sazgarnia, Aminah& Nasiri, Muhammad Rida Ghavam& Amrollahi, Mustafa& Parhiz, Hamidah& Ramezani, Muhammad. In vivo time-dependent radio-protective effect of lycopene against whole-body gamma radiation in mice. Iranian Red Crescent Medical Journal. 2017. Vol. 19, no. 2, pp.1-8.
https://search.emarefa.net/detail/BIM-791805
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 7-8
رقم السجل
BIM-791805
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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