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In vivo time-dependent radio-protective effect of lycopene against whole-body gamma radiation in mice
Joint Authors
Oladi, Muhammad Rida
Sazgarnia, Aminah
Nasiri, Muhammad Rida Ghavam
Amrollahi, Mustafa
Parhiz, Hamidah
Ramezani, Muhammad
Source
Iranian Red Crescent Medical Journal
Issue
Vol. 19, Issue 2 (28 Feb. 2017), pp.1-8, 8 p.
Publisher
Publication Date
2017-02-28
Country of Publication
United Arab Emirates
No. of Pages
8
Main Subjects
Abstract EN
Background: Ionizing radiation has become an essential part of modern medicine.
However, applying the effective dose of ionizing radiation is compromised by its inevitable radiation-induced damage to normal tissues.
Natural products with free radical scavenging, antioxidant activities, and immune stimulatory effects offer suitable radio-protective effects.
Objectives: This study was designed to evaluate the in vivo radio-protective activity of lycopene, a naturally dietary carotenoid, against whole-body gamma-irradiation-induced mortality and sickness in mice.
Methods: In this animal experimental study, lycopene was extracted from tomato paste, characterized, and then administered to mice.
Consecutively, 80 healthy adult male mice were recruited and irradiated individually, and then monitored for irradiation sickness and survival parameters.
Results: Pretreatment with 7 mg/kg dose of lycopene 7 days before irradiation was found to reduce the severity of symptoms of radiation sickness in a 30-day post-radiation monitoring.
Lycopene treatment increased the survival rate.
At the radiation dosage of 8 and 9 Gy, the difference between the survival rates of control and sample groups became significant after day 15 and 25.
Lycopene was also shown to have a protective effect on white blood cell count against 8 and 9 Gy gamma radiations.
Conclusions: Natural and exhibitingwhole-body radio-protective activity, lycopene can be proposed as an effective radio-protector in healthy people who are exposed to radiation, such as radiographers, nuclear pharmacists, and radiologists.
American Psychological Association (APA)
Oladi, Muhammad Rida& Sazgarnia, Aminah& Nasiri, Muhammad Rida Ghavam& Amrollahi, Mustafa& Parhiz, Hamidah& Ramezani, Muhammad. 2017. In vivo time-dependent radio-protective effect of lycopene against whole-body gamma radiation in mice. Iranian Red Crescent Medical Journal،Vol. 19, no. 2, pp.1-8.
https://search.emarefa.net/detail/BIM-791805
Modern Language Association (MLA)
Oladi, Muhammad Rida…[et al.]. In vivo time-dependent radio-protective effect of lycopene against whole-body gamma radiation in mice. Iranian Red Crescent Medical Journal Vol. 19, no. 2 (Feb. 2017), pp.1-8.
https://search.emarefa.net/detail/BIM-791805
American Medical Association (AMA)
Oladi, Muhammad Rida& Sazgarnia, Aminah& Nasiri, Muhammad Rida Ghavam& Amrollahi, Mustafa& Parhiz, Hamidah& Ramezani, Muhammad. In vivo time-dependent radio-protective effect of lycopene against whole-body gamma radiation in mice. Iranian Red Crescent Medical Journal. 2017. Vol. 19, no. 2, pp.1-8.
https://search.emarefa.net/detail/BIM-791805
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 7-8
Record ID
BIM-791805