The effect of naltrexone on memory deficit followed by electroconvulsive therapy : a randomized, double-blind placebo-controlled trial
المؤلفون المشاركون
Mutazz al-Din, Sumayyah
Nurbakhsh, Simasadat
Jafari, Rayhanah
Faghihi Muhammadi, Muhammad Mahdi
Shams, Jamal
Zahir al-Din, Ali Rida
المصدر
Iranian Red Crescent Medical Journal
العدد
المجلد 19، العدد 9 (30 سبتمبر/أيلول 2017)، ص ص. 1-9، 9ص.
الناشر
تاريخ النشر
2017-09-30
دولة النشر
الإمارات العربية المتحدة
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Background : Electroconvulsive therapy (ECT) is famously known as a treatment for depression; however, memory impairments have always been a point of concern.
The use of opioid antagonists may protect against the development of memory deficits after ECT.
The current study aimed at assessing the effect of Naltrexone in diminishing memory impairments.
Methods : This randomized, double-blinded, placebo-controlled clinical trial took place at Imam Hossein hospital of Tehran/Iran.
Patients diagnosed withMDD, were assigned to either Naltrexone or placebo and received 6 sessions of ECT within 2 weeks.Wechsler Memory Scale was performed the day before the first session of ECT, as well as 2 weeks, 1 and 3 months after finishing the 6th session.
The Hamilton depression rating scale was performed 2 times to examine the possible interference caused by depression or to relapse as a confounding variable.
Results : Patients receiving Naltrexone and placebo showed no significant difference in WMS scores.
However, after further assessment, changes of WMS scores in every round were compared; the results showed that after 2 weeks from baseline, the amount of the reduction of total WMS scores from baseline was significantly lower in the Naltrexone group (P = 0.04).
Conclusions : This study suggests that Naltrexone as compared to placebo has no advantageous effect on attenuating memory deficits in the long term.
It is a smaller degree of memory decline that makes Naltrexone superior to placebo
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Mutazz al-Din, Sumayyah& Nurbakhsh, Simasadat& Shams, Jamal& Jafari, Rayhanah& Faghihi Muhammadi, Muhammad Mahdi& Zahir al-Din, Ali Rida. 2017. The effect of naltrexone on memory deficit followed by electroconvulsive therapy : a randomized, double-blind placebo-controlled trial. Iranian Red Crescent Medical Journal،Vol. 19, no. 9, pp.1-9.
https://search.emarefa.net/detail/BIM-796208
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Mutazz al-Din, Sumayyah…[et al.]. The effect of naltrexone on memory deficit followed by electroconvulsive therapy : a randomized, double-blind placebo-controlled trial. Iranian Red Crescent Medical Journal Vol. 19, no. 9 (Sep. 2017), pp.1-9.
https://search.emarefa.net/detail/BIM-796208
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Mutazz al-Din, Sumayyah& Nurbakhsh, Simasadat& Shams, Jamal& Jafari, Rayhanah& Faghihi Muhammadi, Muhammad Mahdi& Zahir al-Din, Ali Rida. The effect of naltrexone on memory deficit followed by electroconvulsive therapy : a randomized, double-blind placebo-controlled trial. Iranian Red Crescent Medical Journal. 2017. Vol. 19, no. 9, pp.1-9.
https://search.emarefa.net/detail/BIM-796208
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 8-9
رقم السجل
BIM-796208
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر