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The effect of naltrexone on memory deficit followed by electroconvulsive therapy : a randomized, double-blind placebo-controlled trial
Joint Authors
Mutazz al-Din, Sumayyah
Nurbakhsh, Simasadat
Jafari, Rayhanah
Faghihi Muhammadi, Muhammad Mahdi
Shams, Jamal
Zahir al-Din, Ali Rida
Source
Iranian Red Crescent Medical Journal
Issue
Vol. 19, Issue 9 (30 Sep. 2017), pp.1-9, 9 p.
Publisher
Publication Date
2017-09-30
Country of Publication
United Arab Emirates
No. of Pages
9
Main Subjects
Abstract EN
Background : Electroconvulsive therapy (ECT) is famously known as a treatment for depression; however, memory impairments have always been a point of concern.
The use of opioid antagonists may protect against the development of memory deficits after ECT.
The current study aimed at assessing the effect of Naltrexone in diminishing memory impairments.
Methods : This randomized, double-blinded, placebo-controlled clinical trial took place at Imam Hossein hospital of Tehran/Iran.
Patients diagnosed withMDD, were assigned to either Naltrexone or placebo and received 6 sessions of ECT within 2 weeks.Wechsler Memory Scale was performed the day before the first session of ECT, as well as 2 weeks, 1 and 3 months after finishing the 6th session.
The Hamilton depression rating scale was performed 2 times to examine the possible interference caused by depression or to relapse as a confounding variable.
Results : Patients receiving Naltrexone and placebo showed no significant difference in WMS scores.
However, after further assessment, changes of WMS scores in every round were compared; the results showed that after 2 weeks from baseline, the amount of the reduction of total WMS scores from baseline was significantly lower in the Naltrexone group (P = 0.04).
Conclusions : This study suggests that Naltrexone as compared to placebo has no advantageous effect on attenuating memory deficits in the long term.
It is a smaller degree of memory decline that makes Naltrexone superior to placebo
American Psychological Association (APA)
Mutazz al-Din, Sumayyah& Nurbakhsh, Simasadat& Shams, Jamal& Jafari, Rayhanah& Faghihi Muhammadi, Muhammad Mahdi& Zahir al-Din, Ali Rida. 2017. The effect of naltrexone on memory deficit followed by electroconvulsive therapy : a randomized, double-blind placebo-controlled trial. Iranian Red Crescent Medical Journal،Vol. 19, no. 9, pp.1-9.
https://search.emarefa.net/detail/BIM-796208
Modern Language Association (MLA)
Mutazz al-Din, Sumayyah…[et al.]. The effect of naltrexone on memory deficit followed by electroconvulsive therapy : a randomized, double-blind placebo-controlled trial. Iranian Red Crescent Medical Journal Vol. 19, no. 9 (Sep. 2017), pp.1-9.
https://search.emarefa.net/detail/BIM-796208
American Medical Association (AMA)
Mutazz al-Din, Sumayyah& Nurbakhsh, Simasadat& Shams, Jamal& Jafari, Rayhanah& Faghihi Muhammadi, Muhammad Mahdi& Zahir al-Din, Ali Rida. The effect of naltrexone on memory deficit followed by electroconvulsive therapy : a randomized, double-blind placebo-controlled trial. Iranian Red Crescent Medical Journal. 2017. Vol. 19, no. 9, pp.1-9.
https://search.emarefa.net/detail/BIM-796208
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 8-9
Record ID
BIM-796208