The effect of symbiotic supplementation on body composition and lipid profile in patients with NAFLD : a randomized, double blind, placebo-controlled clinical trial study
المؤلفون المشاركون
Zadah, Ahmad Ismail
Muhammadi, Vida
Askari, Ghulam Rida
Asgharian, Atif
Ghuli, Zahrah
Feizi, Awat
المصدر
Iranian Red Crescent Medical Journal
العدد
المجلد 19، العدد 4 (30 إبريل/نيسان 2017)، ص ص. 1-7، 7ص.
الناشر
تاريخ النشر
2017-04-30
دولة النشر
الإمارات العربية المتحدة
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Background: Regarding the growing prevalence of non-alcoholic fatty liver disease, concentrating on various strategies for its prevention and management seems necessary.
Objectives: This study aimed to assess the effects of synbiotic administration on body composition and lipid profile in patientswith NAFLD.
Methods: Eighty patients with NAFLD participated in this randomized, double-blind, placebo-controlled clinical trial (from March to July 2014) in Iran.
Based on AST and ALT as main variables of the study, 34 patients were required in each group (power 80% and α = 5%).
Considering a 20% sample loss, 80 patients were enrolled.
Synbiotic supplement in form of a 500 mg capsule (containing 7 species of probiotic bacteria and Fructooligosaccharides) was administrated to patients in the intervention group and those in the placebo group received 1 placebo capsule daily for 8 weeks.
At the baseline and the end of the study, body composition and lipid profile were evaluated.
Results: A significant reduction was observed in weight (P = 0.001), body fat (P = 0.02), and total cholesterol (P = 0.04) within the synbiotic group.
On the other hand, WC (P = 0.02), total cholesterol, and LDL-c(P = 0.04 and P = 0.001, respectively) were significantly increased in the placebo group.
TG, HDL-c, and FBG levels remained statistically unchanged in both groups.
Significance betweengroup differences were seen in total cholesterol (P = 0.01), LDL (P = 0.01), weight, WC, and body fat after adjustment for energy intake (P = 0.05).
Conclusions: Synbiotic supplementation may improve lipid profile and body composition in patients with NAFLD and might be useful in prevention of the disease progression.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Asgharian, Atif& Muhammadi, Vida& Ghuli, Zahrah& Zadah, Ahmad Ismail& Feizi, Awat& Askari, Ghulam Rida. 2017. The effect of symbiotic supplementation on body composition and lipid profile in patients with NAFLD : a randomized, double blind, placebo-controlled clinical trial study. Iranian Red Crescent Medical Journal،Vol. 19, no. 4, pp.1-7.
https://search.emarefa.net/detail/BIM-796818
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Asgharian, Atif…[et al.]. The effect of symbiotic supplementation on body composition and lipid profile in patients with NAFLD : a randomized, double blind, placebo-controlled clinical trial study. Iranian Red Crescent Medical Journal Vol. 19, no. 4 (Apr. 2017), pp.1-7.
https://search.emarefa.net/detail/BIM-796818
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Asgharian, Atif& Muhammadi, Vida& Ghuli, Zahrah& Zadah, Ahmad Ismail& Feizi, Awat& Askari, Ghulam Rida. The effect of symbiotic supplementation on body composition and lipid profile in patients with NAFLD : a randomized, double blind, placebo-controlled clinical trial study. Iranian Red Crescent Medical Journal. 2017. Vol. 19, no. 4, pp.1-7.
https://search.emarefa.net/detail/BIM-796818
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 6-7
رقم السجل
BIM-796818
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر