The effect of symbiotic supplementation on body composition and lipid profile in patients with NAFLD : a randomized, double blind, placebo-controlled clinical trial study
Joint Authors
Zadah, Ahmad Ismail
Muhammadi, Vida
Askari, Ghulam Rida
Asgharian, Atif
Ghuli, Zahrah
Feizi, Awat
Source
Iranian Red Crescent Medical Journal
Issue
Vol. 19, Issue 4 (30 Apr. 2017), pp.1-7, 7 p.
Publisher
Publication Date
2017-04-30
Country of Publication
United Arab Emirates
No. of Pages
7
Main Subjects
Abstract EN
Background: Regarding the growing prevalence of non-alcoholic fatty liver disease, concentrating on various strategies for its prevention and management seems necessary.
Objectives: This study aimed to assess the effects of synbiotic administration on body composition and lipid profile in patientswith NAFLD.
Methods: Eighty patients with NAFLD participated in this randomized, double-blind, placebo-controlled clinical trial (from March to July 2014) in Iran.
Based on AST and ALT as main variables of the study, 34 patients were required in each group (power 80% and α = 5%).
Considering a 20% sample loss, 80 patients were enrolled.
Synbiotic supplement in form of a 500 mg capsule (containing 7 species of probiotic bacteria and Fructooligosaccharides) was administrated to patients in the intervention group and those in the placebo group received 1 placebo capsule daily for 8 weeks.
At the baseline and the end of the study, body composition and lipid profile were evaluated.
Results: A significant reduction was observed in weight (P = 0.001), body fat (P = 0.02), and total cholesterol (P = 0.04) within the synbiotic group.
On the other hand, WC (P = 0.02), total cholesterol, and LDL-c(P = 0.04 and P = 0.001, respectively) were significantly increased in the placebo group.
TG, HDL-c, and FBG levels remained statistically unchanged in both groups.
Significance betweengroup differences were seen in total cholesterol (P = 0.01), LDL (P = 0.01), weight, WC, and body fat after adjustment for energy intake (P = 0.05).
Conclusions: Synbiotic supplementation may improve lipid profile and body composition in patients with NAFLD and might be useful in prevention of the disease progression.
American Psychological Association (APA)
Asgharian, Atif& Muhammadi, Vida& Ghuli, Zahrah& Zadah, Ahmad Ismail& Feizi, Awat& Askari, Ghulam Rida. 2017. The effect of symbiotic supplementation on body composition and lipid profile in patients with NAFLD : a randomized, double blind, placebo-controlled clinical trial study. Iranian Red Crescent Medical Journal،Vol. 19, no. 4, pp.1-7.
https://search.emarefa.net/detail/BIM-796818
Modern Language Association (MLA)
Asgharian, Atif…[et al.]. The effect of symbiotic supplementation on body composition and lipid profile in patients with NAFLD : a randomized, double blind, placebo-controlled clinical trial study. Iranian Red Crescent Medical Journal Vol. 19, no. 4 (Apr. 2017), pp.1-7.
https://search.emarefa.net/detail/BIM-796818
American Medical Association (AMA)
Asgharian, Atif& Muhammadi, Vida& Ghuli, Zahrah& Zadah, Ahmad Ismail& Feizi, Awat& Askari, Ghulam Rida. The effect of symbiotic supplementation on body composition and lipid profile in patients with NAFLD : a randomized, double blind, placebo-controlled clinical trial study. Iranian Red Crescent Medical Journal. 2017. Vol. 19, no. 4, pp.1-7.
https://search.emarefa.net/detail/BIM-796818
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 6-7
Record ID
BIM-796818