Effect of vincristine and vinblastine from Vinca rosa on microtubulues of tumor H22 cell line (hepatic cell line)‎

المؤلفون المشاركون

Muhammad, Ibrahim Hadi
Abd al-Latif, Maryam Hikmat

المصدر

Iraqi Journal of Biotechnology

العدد

المجلد 16، العدد 3 (30 سبتمبر/أيلول 2017)، ص ص. 129-136، 8ص.

الناشر

جامعة بغداد معهد الهندسة الوراثية و التقنيات الإحيائية للدراسات العليا

تاريخ النشر

2017-09-30

دولة النشر

العراق

عدد الصفحات

8

التخصصات الرئيسية

الأحياء

الملخص EN

Vinca alkaloids (Vincristinc and Vinblastinc) arc microtubular toxins of chemically similar nature that disrupt microtubulc function by binding to a site on f^-tubulin and suppressing microtubulc dynamics.

The study aims to evaluate biological activity of Vincristinc and Vinblastinc on microtubulc H22 cell line using GF tubulin.

Stable tumor cell line of H>2 ccll was used to investigatc the action of vincristine and vinblastinc on the microtubulc network.

An expérimental work was conductcd to détermine the biological activity of vincristinc and vinblastinc on microtubulc H22 ccll line by used CïF tubulin.

Cells were treatcd with Vincristine and Vinblastinc at various concentrations from 20 pg ml to 400 jig/ml for 60 min..

Microtubulcs were detected by mcans of indirect immunofluorescence.

No différences were found between the two cytostatics.

As a conclusion, the cells showed changes in the arrangement of microtubulcs even at the 80 pg/ml concentration of cytostatics after 60-min exposition.

Its damage increased with increasing concentration of cytostatics.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Muhammad, Ibrahim Hadi& Abd al-Latif, Maryam Hikmat. 2017. Effect of vincristine and vinblastine from Vinca rosa on microtubulues of tumor H22 cell line (hepatic cell line). Iraqi Journal of Biotechnology،Vol. 16, no. 3, pp.129-136.
https://search.emarefa.net/detail/BIM-811036

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Muhammad, Ibrahim Hadi& Abd al-Latif, Maryam Hikmat. Effect of vincristine and vinblastine from Vinca rosa on microtubulues of tumor H22 cell line (hepatic cell line). Iraqi Journal of Biotechnology Vol. 16, no. 3 (2017), pp.129-136.
https://search.emarefa.net/detail/BIM-811036

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Muhammad, Ibrahim Hadi& Abd al-Latif, Maryam Hikmat. Effect of vincristine and vinblastine from Vinca rosa on microtubulues of tumor H22 cell line (hepatic cell line). Iraqi Journal of Biotechnology. 2017. Vol. 16, no. 3, pp.129-136.
https://search.emarefa.net/detail/BIM-811036

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references : p. 135-136

رقم السجل

BIM-811036