Ethanol-induced white matter atrophy is associated with impaired expression of aspartyl-asparaginyl-β-hydroxylase (ASPH) and notch signaling in an experimental rat model
المؤلفون المشاركون
Tong, Ming
Yalcin, Emine B.
De La Monte, Suzanne M.
Gonzalez Navarrete, Howard
Kirchberg, Tyler
Gotama, Billy
Kay, Jared
المصدر
Journal of Drug and Alcohol Research
العدد
المجلد 6، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-12، 12ص.
الناشر
تاريخ النشر
2017-12-31
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
العلوم الطبية والصيدلة والعلوم الصحية
الملخص EN
Background.
Alcohol-induced white matter (WM) degeneration is linked to cognitive-motor deficits and impaired insulin/IGF and Notch networks that regulate oligodendrocyte function.
Ethanol also down-regulates expression of ASPH which drives Notch.
Objective.
Experiments were designed to determine if alcohol-related WM atrophy was linked to inhibition of ASPH and Notch.
Methods.
Adult Long Evans rats were fed for 3, 6, or 8 weeks with liquid diets containing 0% or 26% ethanol (caloric).
During the last 2 weeks of each endpoint, ethanol-exposed rats were binged with 2 g/kg ethanol, 3×/week.
Frontal lobe and cerebellar histological sections were used for image analysis and frontal WMwas used for protein studies.
Results.
Ethanol caused exposure duration-dependent reductions in frontal and cerebellar WM content.
WM atrophy was associated with reduced expression of ASPH, Jagged-1, HES-1, and HIF-1α.
Conclusions.
These new findings link ethanol-induced WM atrophy to inhibition of ASPH expression and Notch network signaling, providing additional potential targets for treatment of alcoholic brain disease
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Tong, Ming& Gonzalez Navarrete, Howard& Kirchberg, Tyler& Gotama, Billy& Yalcin, Emine B.& Kay, Jared…[et al.]. 2017. Ethanol-induced white matter atrophy is associated with impaired expression of aspartyl-asparaginyl-β-hydroxylase (ASPH) and notch signaling in an experimental rat model. Journal of Drug and Alcohol Research،Vol. 6, no. 2017, pp.1-12.
https://search.emarefa.net/detail/BIM-812792
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Tong, Ming…[et al.]. Ethanol-induced white matter atrophy is associated with impaired expression of aspartyl-asparaginyl-β-hydroxylase (ASPH) and notch signaling in an experimental rat model. Journal of Drug and Alcohol Research Vol. 6 (2017), pp.1-12.
https://search.emarefa.net/detail/BIM-812792
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Tong, Ming& Gonzalez Navarrete, Howard& Kirchberg, Tyler& Gotama, Billy& Yalcin, Emine B.& Kay, Jared…[et al.]. Ethanol-induced white matter atrophy is associated with impaired expression of aspartyl-asparaginyl-β-hydroxylase (ASPH) and notch signaling in an experimental rat model. Journal of Drug and Alcohol Research. 2017. Vol. 6, no. 2017, pp.1-12.
https://search.emarefa.net/detail/BIM-812792
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 10-12
رقم السجل
BIM-812792
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر