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Ethanol-induced white matter atrophy is associated with impaired expression of aspartyl-asparaginyl-β-hydroxylase (ASPH) and notch signaling in an experimental rat model
Joint Authors
Tong, Ming
Yalcin, Emine B.
De La Monte, Suzanne M.
Gonzalez Navarrete, Howard
Kirchberg, Tyler
Gotama, Billy
Kay, Jared
Source
Journal of Drug and Alcohol Research
Issue
Vol. 6, Issue 2017 (31 Dec. 2017), pp.1-12, 12 p.
Publisher
Publication Date
2017-12-31
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Pharmacy, Health & Medical Sciences
Abstract EN
Background.
Alcohol-induced white matter (WM) degeneration is linked to cognitive-motor deficits and impaired insulin/IGF and Notch networks that regulate oligodendrocyte function.
Ethanol also down-regulates expression of ASPH which drives Notch.
Objective.
Experiments were designed to determine if alcohol-related WM atrophy was linked to inhibition of ASPH and Notch.
Methods.
Adult Long Evans rats were fed for 3, 6, or 8 weeks with liquid diets containing 0% or 26% ethanol (caloric).
During the last 2 weeks of each endpoint, ethanol-exposed rats were binged with 2 g/kg ethanol, 3×/week.
Frontal lobe and cerebellar histological sections were used for image analysis and frontal WMwas used for protein studies.
Results.
Ethanol caused exposure duration-dependent reductions in frontal and cerebellar WM content.
WM atrophy was associated with reduced expression of ASPH, Jagged-1, HES-1, and HIF-1α.
Conclusions.
These new findings link ethanol-induced WM atrophy to inhibition of ASPH expression and Notch network signaling, providing additional potential targets for treatment of alcoholic brain disease
American Psychological Association (APA)
Tong, Ming& Gonzalez Navarrete, Howard& Kirchberg, Tyler& Gotama, Billy& Yalcin, Emine B.& Kay, Jared…[et al.]. 2017. Ethanol-induced white matter atrophy is associated with impaired expression of aspartyl-asparaginyl-β-hydroxylase (ASPH) and notch signaling in an experimental rat model. Journal of Drug and Alcohol Research،Vol. 6, no. 2017, pp.1-12.
https://search.emarefa.net/detail/BIM-812792
Modern Language Association (MLA)
Tong, Ming…[et al.]. Ethanol-induced white matter atrophy is associated with impaired expression of aspartyl-asparaginyl-β-hydroxylase (ASPH) and notch signaling in an experimental rat model. Journal of Drug and Alcohol Research Vol. 6 (2017), pp.1-12.
https://search.emarefa.net/detail/BIM-812792
American Medical Association (AMA)
Tong, Ming& Gonzalez Navarrete, Howard& Kirchberg, Tyler& Gotama, Billy& Yalcin, Emine B.& Kay, Jared…[et al.]. Ethanol-induced white matter atrophy is associated with impaired expression of aspartyl-asparaginyl-β-hydroxylase (ASPH) and notch signaling in an experimental rat model. Journal of Drug and Alcohol Research. 2017. Vol. 6, no. 2017, pp.1-12.
https://search.emarefa.net/detail/BIM-812792
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 10-12
Record ID
BIM-812792