Alcohol-induced increases in inflammatory cytokines are attenuated by nicotine in region-selective manner in male rats
المؤلفون المشاركون
Kalejaiye, Olubukola
Taylor, Robert E.
Tizabi, Yusuf
Getachew, Bruk
Ferguson, Clifford L.
المصدر
Journal of Drug and Alcohol Research
العدد
المجلد 6، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-6، 6ص.
الناشر
تاريخ النشر
2017-12-31
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
العلوم الطبية والصيدلة والعلوم الصحية
الملخص EN
Background.
Heavy use of alcohol is commonly associated with heavy smoking (nicotine intake).
Although many factors, including mood effects of these two drugs may contribute to their co-use, the exact neurobiological underpinnings are far from clear.
It is well known that chronic alcohol exposure induces neuroinflammation that may precipitate depressive-like behavior, which is considered an important factor in alcohol relapse.
Nicotine, on the other hand, possesses anti-inflammatory and antidepressant effects.
Purpose.
In this study, we sought to determine which proinflammatory markers may be associated with the depressogenic effects of chronic alcohol and whether nicotine pretreatment may normalize these changes.
Study design.
For this purpose, we treated adult maleWistar rats with alcohol (1.0 g/kg, IP), nicotine (0.3mg/kg, IP) or their combination once daily for 14 days.
Two prominent proinflammatory cytokines (IL-1β and TNF-α) in two primary brain regions, namely the hippocampus and frontal cortex that are intimately involved in mood regulation, were evaluated.
Results.
Chronic alcohol resulted in increases in both cytokines in both regions as determined by Western blot.
Nicotine completely blocked alcohol-induced effects in the hippocampus, but not in the frontal cortex.
These data suggest that nicotine may mitigate the inflammatory effects of alcohol in brain-selective region.
Hence, the previously observed depressogenic effects of alcohol and the antidepressant effects of nicotine may at least be partially mediated through manipulations of proinflammatory cytokines in the hippocampus.
Conclusion.
These findings suggest possible therapeutic potential of anti-inflammatory cytokines in combating alcohol-induced depression and/or relapse
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Kalejaiye, Olubukola& Getachew, Bruk& Ferguson, Clifford L.& Taylor, Robert E.& Tizabi, Yusuf. 2017. Alcohol-induced increases in inflammatory cytokines are attenuated by nicotine in region-selective manner in male rats. Journal of Drug and Alcohol Research،Vol. 6, no. 2017, pp.1-6.
https://search.emarefa.net/detail/BIM-812795
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Kalejaiye, Olubukola…[et al.]. Alcohol-induced increases in inflammatory cytokines are attenuated by nicotine in region-selective manner in male rats. Journal of Drug and Alcohol Research Vol. 6 (2017), pp.1-6.
https://search.emarefa.net/detail/BIM-812795
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Kalejaiye, Olubukola& Getachew, Bruk& Ferguson, Clifford L.& Taylor, Robert E.& Tizabi, Yusuf. Alcohol-induced increases in inflammatory cytokines are attenuated by nicotine in region-selective manner in male rats. Journal of Drug and Alcohol Research. 2017. Vol. 6, no. 2017, pp.1-6.
https://search.emarefa.net/detail/BIM-812795
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 5-6
رقم السجل
BIM-812795
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر