Alcohol-induced increases in inflammatory cytokines are attenuated by nicotine in region-selective manner in male rats
Joint Authors
Kalejaiye, Olubukola
Taylor, Robert E.
Tizabi, Yusuf
Getachew, Bruk
Ferguson, Clifford L.
Source
Journal of Drug and Alcohol Research
Issue
Vol. 6, Issue 2017 (31 Dec. 2017), pp.1-6, 6 p.
Publisher
Publication Date
2017-12-31
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Pharmacy, Health & Medical Sciences
Abstract EN
Background.
Heavy use of alcohol is commonly associated with heavy smoking (nicotine intake).
Although many factors, including mood effects of these two drugs may contribute to their co-use, the exact neurobiological underpinnings are far from clear.
It is well known that chronic alcohol exposure induces neuroinflammation that may precipitate depressive-like behavior, which is considered an important factor in alcohol relapse.
Nicotine, on the other hand, possesses anti-inflammatory and antidepressant effects.
Purpose.
In this study, we sought to determine which proinflammatory markers may be associated with the depressogenic effects of chronic alcohol and whether nicotine pretreatment may normalize these changes.
Study design.
For this purpose, we treated adult maleWistar rats with alcohol (1.0 g/kg, IP), nicotine (0.3mg/kg, IP) or their combination once daily for 14 days.
Two prominent proinflammatory cytokines (IL-1β and TNF-α) in two primary brain regions, namely the hippocampus and frontal cortex that are intimately involved in mood regulation, were evaluated.
Results.
Chronic alcohol resulted in increases in both cytokines in both regions as determined by Western blot.
Nicotine completely blocked alcohol-induced effects in the hippocampus, but not in the frontal cortex.
These data suggest that nicotine may mitigate the inflammatory effects of alcohol in brain-selective region.
Hence, the previously observed depressogenic effects of alcohol and the antidepressant effects of nicotine may at least be partially mediated through manipulations of proinflammatory cytokines in the hippocampus.
Conclusion.
These findings suggest possible therapeutic potential of anti-inflammatory cytokines in combating alcohol-induced depression and/or relapse
American Psychological Association (APA)
Kalejaiye, Olubukola& Getachew, Bruk& Ferguson, Clifford L.& Taylor, Robert E.& Tizabi, Yusuf. 2017. Alcohol-induced increases in inflammatory cytokines are attenuated by nicotine in region-selective manner in male rats. Journal of Drug and Alcohol Research،Vol. 6, no. 2017, pp.1-6.
https://search.emarefa.net/detail/BIM-812795
Modern Language Association (MLA)
Kalejaiye, Olubukola…[et al.]. Alcohol-induced increases in inflammatory cytokines are attenuated by nicotine in region-selective manner in male rats. Journal of Drug and Alcohol Research Vol. 6 (2017), pp.1-6.
https://search.emarefa.net/detail/BIM-812795
American Medical Association (AMA)
Kalejaiye, Olubukola& Getachew, Bruk& Ferguson, Clifford L.& Taylor, Robert E.& Tizabi, Yusuf. Alcohol-induced increases in inflammatory cytokines are attenuated by nicotine in region-selective manner in male rats. Journal of Drug and Alcohol Research. 2017. Vol. 6, no. 2017, pp.1-6.
https://search.emarefa.net/detail/BIM-812795
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 5-6
Record ID
BIM-812795