The role of clinical, therapeutic and laboratory findings in monitoring of hcmv infection in bonemarrow transplant recipients
المؤلفون المشاركون
Etminan, H.
Yaghoobi, Ramin
Ramzi, Muhammad
المصدر
Iranian Red Crescent Medical Journal
العدد
المجلد 11، العدد 1 (31 يناير/كانون الثاني 2009)، ص ص. 46-51، 6ص.
الناشر
تاريخ النشر
2009-01-31
دولة النشر
الإمارات العربية المتحدة
عدد الصفحات
6
التخصصات الرئيسية
الموضوعات
الملخص EN
Background : human cytomegalovirus (HCMV) has been an enormous threat for bone marrow transplant (BMT) recipients.
For active and / or latent HCMV infection, diagnosis of the risk factors which increase the risk of posttransplant morbidity and mortality seems necessary.
In this research, some of the HCMV risk factors were monitored and compared with HCMV molecular diagnostic methods for better detection of HCMV infection in BMT patients Methods : hCMV risk factors including clinical, biological, biochemical, hematological indexes, and also anti HCMV and transplant prophylactic and therapeutic conditioning regimens were monitored from March 2002 to March 2006, in 104 BMT patients referred to BMT Unit of Nemazee Hospital in Shiraz University of Medical Sciences and was compared with HCMV molecular methods for BMT donors and recipients' pre-and post transplantation.
Results : Anti-HCMV-lgM was detected in 9.6 % and 6.7 % of BMT recipients and donors, respectively.
Anti HCMV-lgG was also detected in 8.7 % and 9.1 % of recipients and donors, pre-transplant, respectively.
HCMVPCR results were positive in 20 % of recipients and 33.3 % of donors.
Significant correlations were observed between HCMV positive results and the use of a therapeutic dose, but not the prophylactic dose of glucocorticoids and cyclosporine, pre and post-transplantation.
Fasting blood sugar, creatinine, globulin, and liver enzymes levels such as alkaline phosphates and asparagine transpherase significantly correlated with detection of HCMVDNA in transplant patients.
Also, negative results of HCMV-PCR significantly correlated with the use of prophylactic dose of acyclovir in BMT patients.
Conclusion : significant correlations of positive and negative HCMV-PCR results with HCMV disease risk factors suggest the possible role of these factors on prognosis and monitoring of HCMV disease in BMT recipients preand post-transplantation.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Ramzi, Muhammad& Yaghoobi, Ramin& Etminan, H.. 2009. The role of clinical, therapeutic and laboratory findings in monitoring of hcmv infection in bonemarrow transplant recipients. Iranian Red Crescent Medical Journal،Vol. 11, no. 1, pp.46-51.
https://search.emarefa.net/detail/BIM-82280
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Ramzi, Muhammad…[et al.]. The role of clinical, therapeutic and laboratory findings in monitoring of hcmv infection in bonemarrow transplant recipients. Iranian Red Crescent Medical Journal Vol. 11, no. 1 (Jan. 2009), pp.46-51.
https://search.emarefa.net/detail/BIM-82280
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Ramzi, Muhammad& Yaghoobi, Ramin& Etminan, H.. The role of clinical, therapeutic and laboratory findings in monitoring of hcmv infection in bonemarrow transplant recipients. Iranian Red Crescent Medical Journal. 2009. Vol. 11, no. 1, pp.46-51.
https://search.emarefa.net/detail/BIM-82280
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 50-51
رقم السجل
BIM-82280
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر