The role of clinical, therapeutic and laboratory findings in monitoring of hcmv infection in bonemarrow transplant recipients
Joint Authors
Etminan, H.
Yaghoobi, Ramin
Ramzi, Muhammad
Source
Iranian Red Crescent Medical Journal
Issue
Vol. 11, Issue 1 (31 Jan. 2009), pp.46-51, 6 p.
Publisher
Publication Date
2009-01-31
Country of Publication
United Arab Emirates
No. of Pages
6
Main Subjects
Topics
Abstract EN
Background : human cytomegalovirus (HCMV) has been an enormous threat for bone marrow transplant (BMT) recipients.
For active and / or latent HCMV infection, diagnosis of the risk factors which increase the risk of posttransplant morbidity and mortality seems necessary.
In this research, some of the HCMV risk factors were monitored and compared with HCMV molecular diagnostic methods for better detection of HCMV infection in BMT patients Methods : hCMV risk factors including clinical, biological, biochemical, hematological indexes, and also anti HCMV and transplant prophylactic and therapeutic conditioning regimens were monitored from March 2002 to March 2006, in 104 BMT patients referred to BMT Unit of Nemazee Hospital in Shiraz University of Medical Sciences and was compared with HCMV molecular methods for BMT donors and recipients' pre-and post transplantation.
Results : Anti-HCMV-lgM was detected in 9.6 % and 6.7 % of BMT recipients and donors, respectively.
Anti HCMV-lgG was also detected in 8.7 % and 9.1 % of recipients and donors, pre-transplant, respectively.
HCMVPCR results were positive in 20 % of recipients and 33.3 % of donors.
Significant correlations were observed between HCMV positive results and the use of a therapeutic dose, but not the prophylactic dose of glucocorticoids and cyclosporine, pre and post-transplantation.
Fasting blood sugar, creatinine, globulin, and liver enzymes levels such as alkaline phosphates and asparagine transpherase significantly correlated with detection of HCMVDNA in transplant patients.
Also, negative results of HCMV-PCR significantly correlated with the use of prophylactic dose of acyclovir in BMT patients.
Conclusion : significant correlations of positive and negative HCMV-PCR results with HCMV disease risk factors suggest the possible role of these factors on prognosis and monitoring of HCMV disease in BMT recipients preand post-transplantation.
American Psychological Association (APA)
Ramzi, Muhammad& Yaghoobi, Ramin& Etminan, H.. 2009. The role of clinical, therapeutic and laboratory findings in monitoring of hcmv infection in bonemarrow transplant recipients. Iranian Red Crescent Medical Journal،Vol. 11, no. 1, pp.46-51.
https://search.emarefa.net/detail/BIM-82280
Modern Language Association (MLA)
Ramzi, Muhammad…[et al.]. The role of clinical, therapeutic and laboratory findings in monitoring of hcmv infection in bonemarrow transplant recipients. Iranian Red Crescent Medical Journal Vol. 11, no. 1 (Jan. 2009), pp.46-51.
https://search.emarefa.net/detail/BIM-82280
American Medical Association (AMA)
Ramzi, Muhammad& Yaghoobi, Ramin& Etminan, H.. The role of clinical, therapeutic and laboratory findings in monitoring of hcmv infection in bonemarrow transplant recipients. Iranian Red Crescent Medical Journal. 2009. Vol. 11, no. 1, pp.46-51.
https://search.emarefa.net/detail/BIM-82280
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 50-51
Record ID
BIM-82280