Relation of inflammatory markers to severity and activity of chronic rheumatoid arthritis
العناوين الأخرى
العلاقة بين علامات للالتهابات مع شدة و نشاط التهاب المفاصل الروماتويدي المزمن
المؤلفون المشاركون
Rasul, Muhammad T.
Abd Allah, Qasim H.
Hamu, Sadiyah Yasin
المصدر
الناشر
تاريخ النشر
2012-12-31
دولة النشر
العراق
عدد الصفحات
14
التخصصات الرئيسية
الملخص الإنجليزي
Objectives: Assessment of inflammatory markers High sensitive C-reactive protein (Hs-CRP), Anti-CCP, IL1- alpha, IL - 6) in chronic RA patients and its relation to the disease severity and activity.
Methods: This is a case – control study.
The subjects involved in this study were classified into two groups: patients with rheumatoid arthritis (n= 48) and the second group of apparently healthy subjects (n= 30).History and clinical examination were recorded, and then 10 ml of venous blood were obtained from each subject for measurement of ( Hs-CRP),( Anti-ccp), ( IL-1 alpha ), ( IL-6).
Results: More than 50% of RA patients included in this study have DAS28 score more than 5.1 and severe form of the disease.
The mean disease activity score (DAS28) for RA was (5.6 ± 0.17).
The (sever Stanford disability index) was (1.05 ± 0.065).
There were highly significant increases in the mean values of serologic and inflammatory biomarkers if RA patients compared with controls: Anti-ccp antibody (18.7 ±1 .89 vs 5.47 ± 0.42 U/ml, p < 0.001 ), serum Hs-CRP ( 20.59 ± 1.25 vs 4.87 ± 0.52 mg/l, p < 0.001), erythrocyte sedimentation rate (ESR) (41.50 ± 2.67 vs 12.07 ± 1.45 mm/hr, p < 0.001), serum Interleukin 1-alpha (IL-1 alpha) (50.49 ± 3.61 vs 8.03 ± 0.78 picograms, p < 0.001) and Interleukin -6 (IL-6) (86.46 ± 7.33 vs 19.52 ± 1.34 picograms, p < 0.001).
Patients with high DAS28 (≥ 5.1) and severe disability index have higher mean values of serum Anti-CCP and inflammatory biomarkers levels.
Conclusions: Measurement of serum Anti-ccp antibodies concentration is of high value in the diagnosis of RA.
Serum (Hs-CRP, IL-1 alpha, IL-6) can be used as an inflammatory biomarker for evaluating disease activity and severity in RA.
نوع البيانات
أوراق مؤتمرات
رقم السجل
BIM-831963
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Hamu, Sadiyah Yasin& Rasul, Muhammad T.& Abd Allah, Qasim H.. 2012-12-31. Relation of inflammatory markers to severity and activity of chronic rheumatoid arthritis. The Scientific Conference of the Faculty of Medical Sciences (2th : 2012 : University of Duhok, Iraq). . Vol. 6, First supplement (Dec. 2012), pp.28-41.Dihok Iraq : University of Duhok College of Medicine.
https://search.emarefa.net/detail/BIM-831963
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Hamu, Sadiyah Yasin…[et al.]. Relation of inflammatory markers to severity and activity of chronic rheumatoid arthritis. . Dihok Iraq : University of Duhok College of Medicine. 2012-12-31.
https://search.emarefa.net/detail/BIM-831963
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Hamu, Sadiyah Yasin& Rasul, Muhammad T.& Abd Allah, Qasim H.. Relation of inflammatory markers to severity and activity of chronic rheumatoid arthritis. . The Scientific Conference of the Faculty of Medical Sciences (2th : 2012 : University of Duhok, Iraq).
https://search.emarefa.net/detail/BIM-831963
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر