Relation of inflammatory markers to severity and activity of chronic rheumatoid arthritis

العناوين الأخرى

العلاقة بين علامات للالتهابات مع شدة و نشاط التهاب المفاصل الروماتويدي المزمن

المؤلفون المشاركون

Rasul, Muhammad T.
Abd Allah, Qasim H.
Hamu, Sadiyah Yasin

المصدر

Duhok Medical Journal

الناشر

جامعة دهوك كلية الطب

تاريخ النشر

2012-12-31

دولة النشر

العراق

عدد الصفحات

14

التخصصات الرئيسية

الطب البشري

الملخص الإنجليزي

Objectives: Assessment of inflammatory markers High sensitive C-reactive protein (Hs-CRP), Anti-CCP, IL1- alpha, IL - 6) in chronic RA patients and its relation to the disease severity and activity.

Methods: This is a case – control study.

The subjects involved in this study were classified into two groups: patients with rheumatoid arthritis (n= 48) and the second group of apparently healthy subjects (n= 30).History and clinical examination were recorded, and then 10 ml of venous blood were obtained from each subject for measurement of ( Hs-CRP),( Anti-ccp), ( IL-1 alpha ), ( IL-6).

Results: More than 50% of RA patients included in this study have DAS28 score more than 5.1 and severe form of the disease.

The mean disease activity score (DAS28) for RA was (5.6 ± 0.17).

The (sever Stanford disability index) was (1.05 ± 0.065).

There were highly significant increases in the mean values of serologic and inflammatory biomarkers if RA patients compared with controls: Anti-ccp antibody (18.7 ±1 .89 vs 5.47 ± 0.42 U/ml, p < 0.001 ), serum Hs-CRP ( 20.59 ± 1.25 vs 4.87 ± 0.52 mg/l, p < 0.001), erythrocyte sedimentation rate (ESR) (41.50 ± 2.67 vs 12.07 ± 1.45 mm/hr, p < 0.001), serum Interleukin 1-alpha (IL-1 alpha) (50.49 ± 3.61 vs 8.03 ± 0.78 picograms, p < 0.001) and Interleukin -6 (IL-6) (86.46 ± 7.33 vs 19.52 ± 1.34 picograms, p < 0.001).

Patients with high DAS28 (≥ 5.1) and severe disability index have higher mean values of serum Anti-CCP and inflammatory biomarkers levels.

Conclusions: Measurement of serum Anti-ccp antibodies concentration is of high value in the diagnosis of RA.

Serum (Hs-CRP, IL-1 alpha, IL-6) can be used as an inflammatory biomarker for evaluating disease activity and severity in RA.

نوع البيانات

أوراق مؤتمرات

رقم السجل

BIM-831963

• APA
• MLA
• AMA