Relation of inflammatory markers to severity and activity of chronic rheumatoid arthritis

Other Title(s)

العلاقة بين علامات للالتهابات مع شدة و نشاط التهاب المفاصل الروماتويدي المزمن

Joint Authors

Rasul, Muhammad T.
Abd Allah, Qasim H.
Hamu, Sadiyah Yasin

Source

Duhok Medical Journal

Publisher

University of Duhok College of Medicine

Publication Date

2012-12-31

Country of Publication

Iraq

No. of Pages

14

Main Subjects

Medicine

English Abstract

Objectives: Assessment of inflammatory markers High sensitive C-reactive protein (Hs-CRP), Anti-CCP, IL1- alpha, IL - 6) in chronic RA patients and its relation to the disease severity and activity.

Methods: This is a case – control study.

The subjects involved in this study were classified into two groups: patients with rheumatoid arthritis (n= 48) and the second group of apparently healthy subjects (n= 30).History and clinical examination were recorded, and then 10 ml of venous blood were obtained from each subject for measurement of ( Hs-CRP),( Anti-ccp), ( IL-1 alpha ), ( IL-6).

Results: More than 50% of RA patients included in this study have DAS28 score more than 5.1 and severe form of the disease.

The mean disease activity score (DAS28) for RA was (5.6 ± 0.17).

The (sever Stanford disability index) was (1.05 ± 0.065).

There were highly significant increases in the mean values of serologic and inflammatory biomarkers if RA patients compared with controls: Anti-ccp antibody (18.7 ±1 .89 vs 5.47 ± 0.42 U/ml, p < 0.001 ), serum Hs-CRP ( 20.59 ± 1.25 vs 4.87 ± 0.52 mg/l, p < 0.001), erythrocyte sedimentation rate (ESR) (41.50 ± 2.67 vs 12.07 ± 1.45 mm/hr, p < 0.001), serum Interleukin 1-alpha (IL-1 alpha) (50.49 ± 3.61 vs 8.03 ± 0.78 picograms, p < 0.001) and Interleukin -6 (IL-6) (86.46 ± 7.33 vs 19.52 ± 1.34 picograms, p < 0.001).

Patients with high DAS28 (≥ 5.1) and severe disability index have higher mean values of serum Anti-CCP and inflammatory biomarkers levels.

Conclusions: Measurement of serum Anti-ccp antibodies concentration is of high value in the diagnosis of RA.

Serum (Hs-CRP, IL-1 alpha, IL-6) can be used as an inflammatory biomarker for evaluating disease activity and severity in RA.

Data Type

Conference Papers

Record ID

BIM-831963

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