The detection of tumor and inflammatory angiogenic stimulationvia vascular endothelial growth factor (VEGF)‎ expression in relation to microvessel density (MVD)‎ in oral squamous cell carcinoma

العناوين الأخرى

الكشف عن محفز تكوين الأوعية للخلايا السرطانية و الالتهابية عن طريق عامل النمو VEGF بالعلاقة مع تكثف الأوعية الدقيقة في سرطان الفم

المؤلفون المشاركون

Idwar, Luayy
Sabhan, Bashir Jabbar
Yunus, Wasan H.

المصدر

Duhok Medical Journal

الناشر

جامعة دهوك كلية الطب

تاريخ النشر

2012-12-31

دولة النشر

العراق

عدد الصفحات

12

التخصصات الرئيسية

الطب البشري

الملخص الإنجليزي

Background: Tumor growth is angiogenesis-dependent process that is mediated by growth factors such as vascular endothelial growth factor (VEGF).

The main goal of this study is to detect VEGF expression by tumor cells and tumor -associated inflammatory cells to be correlated with microvessel density (MvD) in Oral squamous cell carcinomas.

Materials and Methods: The study included 30 Paraffin embedded tissue blocks that are diagnosed as oral squamous cell carcinoma.

An immunohistochemical staining with anti VEGF and anti CD34 antibodies were performed.

Results: VEGF expression was moderately correlated with tumor site (r=0.34), highly correlated with tumor size and histopathological grade (r=0.97, r=0.71) respectively, and weakly correlated with lymph node involvement (r=0.25).

There was moderate -strong correlation between VEGF expression in both tumor cells and inflammatory cells (r=0.69).

MvD showed a strong correlation with tumor size, tumor site and moderate correlation with histopathological grading.

A highly significant difference was found in MvD with VEGF expression, but, in a weak correlation between them.

There was a very weak correlation of VEGF expression in inflammatory cells with MvD .

Conclusion: VEGF upregulation is correlated to tumor angiogenesis.

In addition, both tumor cells and inflammatory cells namely macrophages, were identified as contributors for VEGF expression in the tissue.

نوع البيانات

أوراق مؤتمرات

رقم السجل

BIM-831967

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