The detection of tumor and inflammatory angiogenic stimulationvia vascular endothelial growth factor (VEGF) expression in relation to microvessel density (MVD) in oral squamous cell carcinoma
Other Title(s)
الكشف عن محفز تكوين الأوعية للخلايا السرطانية و الالتهابية عن طريق عامل النمو VEGF بالعلاقة مع تكثف الأوعية الدقيقة في سرطان الفم
Joint Authors
Idwar, Luayy
Sabhan, Bashir Jabbar
Yunus, Wasan H.
Source
Publisher
University of Duhok College of Medicine
Publication Date
2012-12-31
Country of Publication
Iraq
No. of Pages
12
Main Subjects
English Abstract
Background: Tumor growth is angiogenesis-dependent process that is mediated by growth factors such as vascular endothelial growth factor (VEGF).
The main goal of this study is to detect VEGF expression by tumor cells and tumor -associated inflammatory cells to be correlated with microvessel density (MvD) in Oral squamous cell carcinomas.
Materials and Methods: The study included 30 Paraffin embedded tissue blocks that are diagnosed as oral squamous cell carcinoma.
An immunohistochemical staining with anti VEGF and anti CD34 antibodies were performed.
Results: VEGF expression was moderately correlated with tumor site (r=0.34), highly correlated with tumor size and histopathological grade (r=0.97, r=0.71) respectively, and weakly correlated with lymph node involvement (r=0.25).
There was moderate -strong correlation between VEGF expression in both tumor cells and inflammatory cells (r=0.69).
MvD showed a strong correlation with tumor size, tumor site and moderate correlation with histopathological grading.
A highly significant difference was found in MvD with VEGF expression, but, in a weak correlation between them.
There was a very weak correlation of VEGF expression in inflammatory cells with MvD .
Conclusion: VEGF upregulation is correlated to tumor angiogenesis.
In addition, both tumor cells and inflammatory cells namely macrophages, were identified as contributors for VEGF expression in the tissue.
Data Type
Conference Papers
Record ID
BIM-831967
American Psychological Association (APA)
Yunus, Wasan H.& Idwar, Luayy& Sabhan, Bashir Jabbar. 2012-12-31. The detection of tumor and inflammatory angiogenic stimulationvia vascular endothelial growth factor (VEGF) expression in relation to microvessel density (MVD) in oral squamous cell carcinoma. The Scientific Conference of the Faculty of Medical Sciences (2th : 2012 : University of Duhok, Iraq). . Vol. 6, First supplement (Dec. 2012), pp.42-53.Dihok Iraq : University of Duhok College of Medicine.
https://search.emarefa.net/detail/BIM-831967
Modern Language Association (MLA)
Yunus, Wasan H.…[et al.]. The detection of tumor and inflammatory angiogenic stimulationvia vascular endothelial growth factor (VEGF) expression in relation to microvessel density (MVD) in oral squamous cell carcinoma. . Dihok Iraq : University of Duhok College of Medicine. 2012-12-31.
https://search.emarefa.net/detail/BIM-831967
American Medical Association (AMA)
Yunus, Wasan H.& Idwar, Luayy& Sabhan, Bashir Jabbar. The detection of tumor and inflammatory angiogenic stimulationvia vascular endothelial growth factor (VEGF) expression in relation to microvessel density (MVD) in oral squamous cell carcinoma. . The Scientific Conference of the Faculty of Medical Sciences (2th : 2012 : University of Duhok, Iraq).
https://search.emarefa.net/detail/BIM-831967
