Anti-CCP as a new serologic diagnostic marker for the diagnosis of rheumatoid arthritis patients

العناوين الأخرى

مضادة CCP كعلامة مصل تشخيص جديدة لتشخيص مرضى المفاصل الرثياني

المؤلفون المشاركون

al-Barzinji, Ruqayah Muhammad
Barzinji, Niaz J.
Bustani, Dashty
Abd Allah, Fiyan M.

المصدر

Duhok Medical Journal

الناشر

جامعة دهوك كلية الطب

تاريخ النشر

2012-12-31

دولة النشر

العراق

عدد الصفحات

12

التخصصات الرئيسية

العلوم الطبية والصيدلة والعلوم الصحية

الملخص الإنجليزي

Background and objective: Rheumatoid arthritis (RA) is a systemic autoimmune disease of unknown etiology with chronic joint inflammation.

Anti-cyclic citrullinated peptide (anti-CCP)antibody testing is particularly useful in the diagnosis of RA, with high specificity.

These antibodies also identify a subset of patients who are likely to have substantial ongoing disease activity, more damage, and who will probably benefit most from early aggressive treatment.

This study was conducted to assess the diagnostic value of anti-CCP RA patients.

Methods: This study was carried out on 90 RA patients 17(18.9%) males and 73(81.1%) females who admitted Rizgari Teaching Hospital and 30 healthy controls (HC) in a period between November 2008 and November 2009.

Parameters like RF-latex, erythrocyte sedimentation rate(ESR), C-reactive protein (CRP)tests were performed on 90 RA patients and 30 HC.

Study groups were tested for enzyme linked immuno-sorbent assay (ELISA) anti-CCP, RF-IgM, RF-IgG and RF-IgA.

Results: Out of 90 RA patients assessed, 60(66.7%) were RF-latex test positive.

Regarding RA serological markers, the best specificity and sensitivity recorded by anti-CCP antibodies were (96.2%) and (73.7%).

AntiCCP test showed significant and highly significant correlation with RF-latex and RF-isotypes respectively.

Moreover, a significant difference (P<0.05) was observed in mean serum concentration between anti-CCP+ve and anti-CCP-ve patients concerning RF-(latex and IgA) and P<0.01 was observed regarding RF-(IgM and IgG).

نوع البيانات

أوراق مؤتمرات

رقم السجل

BIM-832231

• APA
• MLA
• AMA