Anti-CCP as a new serologic diagnostic marker for the diagnosis of rheumatoid arthritis patients
Other Title(s)
مضادة CCP كعلامة مصل تشخيص جديدة لتشخيص مرضى المفاصل الرثياني
Joint Authors
al-Barzinji, Ruqayah Muhammad
Barzinji, Niaz J.
Bustani, Dashty
Abd Allah, Fiyan M.
Source
Publisher
University of Duhok College of Medicine
Publication Date
2012-12-31
Country of Publication
Iraq
No. of Pages
12
Main Subjects
Pharmacy, Health & Medical Sciences
English Abstract
Background and objective: Rheumatoid arthritis (RA) is a systemic autoimmune disease of unknown etiology with chronic joint inflammation.
Anti-cyclic citrullinated peptide (anti-CCP)antibody testing is particularly useful in the diagnosis of RA, with high specificity.
These antibodies also identify a subset of patients who are likely to have substantial ongoing disease activity, more damage, and who will probably benefit most from early aggressive treatment.
This study was conducted to assess the diagnostic value of anti-CCP RA patients.
Methods: This study was carried out on 90 RA patients 17(18.9%) males and 73(81.1%) females who admitted Rizgari Teaching Hospital and 30 healthy controls (HC) in a period between November 2008 and November 2009.
Parameters like RF-latex, erythrocyte sedimentation rate(ESR), C-reactive protein (CRP)tests were performed on 90 RA patients and 30 HC.
Study groups were tested for enzyme linked immuno-sorbent assay (ELISA) anti-CCP, RF-IgM, RF-IgG and RF-IgA.
Results: Out of 90 RA patients assessed, 60(66.7%) were RF-latex test positive.
Regarding RA serological markers, the best specificity and sensitivity recorded by anti-CCP antibodies were (96.2%) and (73.7%).
AntiCCP test showed significant and highly significant correlation with RF-latex and RF-isotypes respectively.
Moreover, a significant difference (P<0.05) was observed in mean serum concentration between anti-CCP+ve and anti-CCP-ve patients concerning RF-(latex and IgA) and P<0.01 was observed regarding RF-(IgM and IgG).
Data Type
Conference Papers
Record ID
BIM-832231
American Psychological Association (APA)
al-Barzinji, Ruqayah Muhammad& Barzinji, Niaz J.& Bustani, Dashty& Abd Allah, Fiyan M.. 2012-12-31. Anti-CCP as a new serologic diagnostic marker for the diagnosis of rheumatoid arthritis patients. The Scientific Conference of the Faculty of Medical Sciences (2th : 2012 : University of Duhok, Iraq). . Vol. 6, Third special issue (Dec. 2012), pp.47-58.Dihok Iraq : University of Duhok College of Medicine.
https://search.emarefa.net/detail/BIM-832231
Modern Language Association (MLA)
al-Barzinji, Ruqayah Muhammad…[et al.]. Anti-CCP as a new serologic diagnostic marker for the diagnosis of rheumatoid arthritis patients. . Dihok Iraq : University of Duhok College of Medicine. 2012-12-31.
https://search.emarefa.net/detail/BIM-832231
American Medical Association (AMA)
al-Barzinji, Ruqayah Muhammad& Barzinji, Niaz J.& Bustani, Dashty& Abd Allah, Fiyan M.. Anti-CCP as a new serologic diagnostic marker for the diagnosis of rheumatoid arthritis patients. . The Scientific Conference of the Faculty of Medical Sciences (2th : 2012 : University of Duhok, Iraq).
https://search.emarefa.net/detail/BIM-832231
