Formulation and in-vitro release study of vitamin B12 from implant poly-lactic glycolic acid

العناوين الأخرى

دراسة تحرير فيتامين ب 12 من بوليمر حمض بولي لاكتيك جلايكوليك الموضعي

مقدم أطروحة جامعية

al-Mahdawi, Tibah Thair

مشرف أطروحة جامعية

al-Ali, Samir Hasan Husayn
al-Wakil, Jabbar Faraj

الجامعة

جامعة الإسراء

الكلية

كلية الصيدلة

دولة الجامعة

الأردن

الدرجة العلمية

ماجستير

تاريخ الدرجة العلمية

2018

الملخص الإنجليزي

Vitamin B12 (cyanocobalamin) is essential for normal RBC formulation, nerve, proteins in the body, certain enzyme reactions, and neurologic function.

Vitamin B12 is given both as an oral supplement and intramuscular single dose with multiple and consecutive treatment in an injections.

The present research study was carried out to formulate a supplement vitamin B12 in a controlled release dosage form as an implants biodegradable polymers, poly-lactic glycolic acid (PLGA) to increase bioavailability of drug in patients that have poor absorption of vitamin B12 from oral route due to the decrease of intrinsic factor that is responsible for the absorption.

Five different formulation of polymer implant and prepared in a twenty gram batch , according the USA patent 7612176.

The dried and finished product implant weight 1 g contain 5mg of vitamin B12 and characterized for drug content, molecular weight of the polymer, particle size of the embryonic particles, moisture contents and residual solvents (EtOH, DCM, Heptane, and SiO).

In addition, the in vitro release study at blood simulated solution was also performed and samples analyzed throughout 38 day ,the release started ad 21- 24 days continuing to 38 day and release reached to 74.5%.

التخصصات الرئيسية

علم الصيدلة

الموضوعات

• فيتامين ب 12
• الأسيتات

عدد الصفحات

78

قائمة المحتويات

• APA
• MLA
• AMA

لغة النص

الإنجليزية

نوع البيانات

رسائل جامعية

رقم السجل

BIM-832890