Formulation and in-vitro release study of vitamin B12 from implant poly-lactic glycolic acid
Other Title(s)
دراسة تحرير فيتامين ب 12 من بوليمر حمض بولي لاكتيك جلايكوليك الموضعي
Dissertant
Thesis advisor
al-Ali, Samir Hasan Husayn
al-Wakil, Jabbar Faraj
University
Isra University
Faculty
Faculty of Pharmacy
University Country
Jordan
Degree
Master
Degree Date
2018
English Abstract
Vitamin B12 (cyanocobalamin) is essential for normal RBC formulation, nerve, proteins in the body, certain enzyme reactions, and neurologic function.
Vitamin B12 is given both as an oral supplement and intramuscular single dose with multiple and consecutive treatment in an injections.
The present research study was carried out to formulate a supplement vitamin B12 in a controlled release dosage form as an implants biodegradable polymers, poly-lactic glycolic acid (PLGA) to increase bioavailability of drug in patients that have poor absorption of vitamin B12 from oral route due to the decrease of intrinsic factor that is responsible for the absorption.
Five different formulation of polymer implant and prepared in a twenty gram batch , according the USA patent 7612176.
The dried and finished product implant weight 1 g contain 5mg of vitamin B12 and characterized for drug content, molecular weight of the polymer, particle size of the embryonic particles, moisture contents and residual solvents (EtOH, DCM, Heptane, and SiO).
In addition, the in vitro release study at blood simulated solution was also performed and samples analyzed throughout 38 day ,the release started ad 21- 24 days continuing to 38 day and release reached to 74.5%.
Main Subjects
Topics
No. of Pages
78
Table of Contents
Table of contents.
Abstract.
Abstract in Arabic.
Chapter One : Introduction
Chapter Two : Literature review
Chapter Three : Methodology.
Chapter Four : Result.
Chapter Five : Discussion.
Chapter Six : Conclusion
References.
American Psychological Association (APA)
al-Mahdawi, Tibah Thair. (2018). Formulation and in-vitro release study of vitamin B12 from implant poly-lactic glycolic acid. (Master's theses Theses and Dissertations Master). Isra University, Jordan
https://search.emarefa.net/detail/BIM-832890
Modern Language Association (MLA)
al-Mahdawi, Tibah Thair. Formulation and in-vitro release study of vitamin B12 from implant poly-lactic glycolic acid. (Master's theses Theses and Dissertations Master). Isra University. (2018).
https://search.emarefa.net/detail/BIM-832890
American Medical Association (AMA)
al-Mahdawi, Tibah Thair. (2018). Formulation and in-vitro release study of vitamin B12 from implant poly-lactic glycolic acid. (Master's theses Theses and Dissertations Master). Isra University, Jordan
https://search.emarefa.net/detail/BIM-832890
Language
English
Data Type
Arab Theses
Record ID
BIM-832890
