Role of osteopontin and oxidative stress in coronary artery atherosclerosis and ischemic heart failure in type 2 diabetes mellitus
العناوين الأخرى
دور الاوستيوبتين و الإجهاد التأكسدي في تصلب الشريان التاجي و مرض عجز القلب الوعائي في مرضى السكري من النوع الثاني
المؤلفون المشاركون
Abd Allah, Qasim H.
Rasul, Suzan O.
al-Nuaymi, Raid Salim
المصدر
العدد
المجلد 6، العدد (sup2) (31 ديسمبر/كانون الأول 2012)، ص ص. 48-59، 12ص.
الناشر
تاريخ النشر
2012-12-31
دولة النشر
العراق
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
Background and Objectives There is now a consensus that atherosclerosis represents a state of heightened oxidative stress characterized by lipid and protein oxidation in the vascular wall.
The objective of this study was to measure levels of these mediators in the systemic circulation as biomarkers for potential use in risk assessment in patients with type 2 diabetes mellitus.
Methods :This study involved 108 patients with type 2 diabetes mellitus admitted to the angiography department for assessment of coronary artery diseases, divided into 3 groups, 66 patients with positive angiography results, 25 with ischemic heart failure, 17 with negative angio results, we compared them with 30 non diabetic subjects with negative angiography results, assessment of plasma osteopontin, serum soluble receptors for advanced glycation end products and total antioxidants capacity were done by ELISA technique.
Results: serum total antioxidants capacity in diabetic patients with positive angio and diabetic with ischemic heart failure were significantly lower compared with other studied groups (non-diabetic controls and diabetic with negative angio), mean serum soluble receptors for advanced glycation end products level was lowest among diabetics with positive angio and ischemic heart failure and highest in the non-diabetic controls, patients with atherosclerosis proved by angiography (diabetic with positive angio and diabetics with positive angio and ischemic heart failure) showed appreciable and significantly higher levels of plasma osteopontin levels compared with other study groups without atherosclerosis (non-diabetic control and diabetic with negative angio).
Conclusion: Measurement of osteopontin and oxidative stress biomarkers are of value for diagnosis of macrovascular complications in patients with type 2 diabetes mellitus.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Abd Allah, Qasim H.& al-Nuaymi, Raid Salim& Rasul, Suzan O.. 2012. Role of osteopontin and oxidative stress in coronary artery atherosclerosis and ischemic heart failure in type 2 diabetes mellitus. Duhok Medical Journal،Vol. 6, no. (sup2), pp.48-59.
https://search.emarefa.net/detail/BIM-833429
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Abd Allah, Qasim H.…[et al.]. Role of osteopontin and oxidative stress in coronary artery atherosclerosis and ischemic heart failure in type 2 diabetes mellitus. Duhok Medical Journal Vol. 6, Second supplement (Dec. 2012), pp.48-59.
https://search.emarefa.net/detail/BIM-833429
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Abd Allah, Qasim H.& al-Nuaymi, Raid Salim& Rasul, Suzan O.. Role of osteopontin and oxidative stress in coronary artery atherosclerosis and ischemic heart failure in type 2 diabetes mellitus. Duhok Medical Journal. 2012. Vol. 6, no. (sup2), pp.48-59.
https://search.emarefa.net/detail/BIM-833429
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 55-57
رقم السجل
BIM-833429
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر