Role of osteopontin and oxidative stress in coronary artery atherosclerosis and ischemic heart failure in type 2 diabetes mellitus

Abstract EN

Background and Objectives There is now a consensus that atherosclerosis represents a state of heightened oxidative stress characterized by lipid and protein oxidation in the vascular wall.

The objective of this study was to measure levels of these mediators in the systemic circulation as biomarkers for potential use in risk assessment in patients with type 2 diabetes mellitus.

Methods :This study involved 108 patients with type 2 diabetes mellitus admitted to the angiography department for assessment of coronary artery diseases, divided into 3 groups, 66 patients with positive angiography results, 25 with ischemic heart failure, 17 with negative angio results, we compared them with 30 non diabetic subjects with negative angiography results, assessment of plasma osteopontin, serum soluble receptors for advanced glycation end products and total antioxidants capacity were done by ELISA technique.

Results: serum total antioxidants capacity in diabetic patients with positive angio and diabetic with ischemic heart failure were significantly lower compared with other studied groups (non-diabetic controls and diabetic with negative angio), mean serum soluble receptors for advanced glycation end products level was lowest among diabetics with positive angio and ischemic heart failure and highest in the non-diabetic controls, patients with atherosclerosis proved by angiography (diabetic with positive angio and diabetics with positive angio and ischemic heart failure) showed appreciable and significantly higher levels of plasma osteopontin levels compared with other study groups without atherosclerosis (non-diabetic control and diabetic with negative angio).

Conclusion: Measurement of osteopontin and oxidative stress biomarkers are of value for diagnosis of macrovascular complications in patients with type 2 diabetes mellitus.