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Role of osteopontin and oxidative stress in coronary artery atherosclerosis and ischemic heart failure in type 2 diabetes mellitus
Other Title(s)
دور الاوستيوبتين و الإجهاد التأكسدي في تصلب الشريان التاجي و مرض عجز القلب الوعائي في مرضى السكري من النوع الثاني
Joint Authors
Abd Allah, Qasim H.
Rasul, Suzan O.
al-Nuaymi, Raid Salim
Source
Issue
Vol. 6, Issue (sup2) (31 Dec. 2012), pp.48-59, 12 p.
Publisher
University of Duhok College of Medicine
Publication Date
2012-12-31
Country of Publication
Iraq
No. of Pages
12
Main Subjects
Abstract EN
Background and Objectives There is now a consensus that atherosclerosis represents a state of heightened oxidative stress characterized by lipid and protein oxidation in the vascular wall.
The objective of this study was to measure levels of these mediators in the systemic circulation as biomarkers for potential use in risk assessment in patients with type 2 diabetes mellitus.
Methods :This study involved 108 patients with type 2 diabetes mellitus admitted to the angiography department for assessment of coronary artery diseases, divided into 3 groups, 66 patients with positive angiography results, 25 with ischemic heart failure, 17 with negative angio results, we compared them with 30 non diabetic subjects with negative angiography results, assessment of plasma osteopontin, serum soluble receptors for advanced glycation end products and total antioxidants capacity were done by ELISA technique.
Results: serum total antioxidants capacity in diabetic patients with positive angio and diabetic with ischemic heart failure were significantly lower compared with other studied groups (non-diabetic controls and diabetic with negative angio), mean serum soluble receptors for advanced glycation end products level was lowest among diabetics with positive angio and ischemic heart failure and highest in the non-diabetic controls, patients with atherosclerosis proved by angiography (diabetic with positive angio and diabetics with positive angio and ischemic heart failure) showed appreciable and significantly higher levels of plasma osteopontin levels compared with other study groups without atherosclerosis (non-diabetic control and diabetic with negative angio).
Conclusion: Measurement of osteopontin and oxidative stress biomarkers are of value for diagnosis of macrovascular complications in patients with type 2 diabetes mellitus.
American Psychological Association (APA)
Abd Allah, Qasim H.& al-Nuaymi, Raid Salim& Rasul, Suzan O.. 2012. Role of osteopontin and oxidative stress in coronary artery atherosclerosis and ischemic heart failure in type 2 diabetes mellitus. Duhok Medical Journal،Vol. 6, no. (sup2), pp.48-59.
https://search.emarefa.net/detail/BIM-833429
Modern Language Association (MLA)
Abd Allah, Qasim H.…[et al.]. Role of osteopontin and oxidative stress in coronary artery atherosclerosis and ischemic heart failure in type 2 diabetes mellitus. Duhok Medical Journal Vol. 6, Second supplement (Dec. 2012), pp.48-59.
https://search.emarefa.net/detail/BIM-833429
American Medical Association (AMA)
Abd Allah, Qasim H.& al-Nuaymi, Raid Salim& Rasul, Suzan O.. Role of osteopontin and oxidative stress in coronary artery atherosclerosis and ischemic heart failure in type 2 diabetes mellitus. Duhok Medical Journal. 2012. Vol. 6, no. (sup2), pp.48-59.
https://search.emarefa.net/detail/BIM-833429
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 55-57
Record ID
BIM-833429