Effects of lycopene on paraoxonase and adipokines parameters in streptozotocin-induced diabetic rabbits
المؤلفون المشاركون
Said, Husam al-Din Salim Muhammad
Sarhat, Intizar Rifat
المصدر
Journal of Science and Technology : in Natural and Medical Sciences
العدد
المجلد 18، العدد 1 (30 يونيو/حزيران 2017)، ص ص. 1-8، 8ص.
الناشر
جامعة السودان للعلوم و التكنولوجيا عمادة البحث العلمي
تاريخ النشر
2017-06-30
دولة النشر
السودان
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Background: Diabetes mellitus (DM) is a metabolic disease characterized by hyperglycaemia resulting from defects in insulin secretion, insulin action, or both, and occurs in almost all populations of the world a variable prevalence.
Objectives: The current study assessed the impact of lycopene on adipokines and paraoxonase (PON) in stereptozotocin-induced diabetic rabbits.
Materials and Methods: A total of one hundred of rabbits (Albino Rabbits) of both sexes weighing between 1.5-2.1 kg were completely randomized in four groups (G) comprising 25 rabbits each.
Diabetes was induced by a single intraperitoneal injection of streptozotocin (35 mg/kg body weight) feeding on a high fat regimen.
Rabbits in G 3,4 which were administered 10 and 20 mg/kg respectively of lycopene for 4 weeks.
The serum levels of leptin, adiponectin, ghrelin, resistin, and tumour necrosis factor – α (TNF-α) were measured by enzyme-linked immunosorbent assay (ELISA), while serum PON was measured by spectrophotometric method.
SPSS computer software was used for data analysis.
Results:Results showed that lycopene administration at both doses significantly reduced the leptin, resistin, TNF-α, and glucose levels compared to diabetic control groupG2.
Consistent significant increases (p < 0.05) were noticed in the level of paraoxonase, adiponectin, and ghrelin in diabetic rabbits dealt with lycopene in comparison with diabetic rabbits of control group G2.
Conclusions: The high leptin, resistin, and TNF-α levels and oxidative damage whereas low linked with diabetes, were improved with the administration of lycopene.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Sarhat, Intizar Rifat& Said, Husam al-Din Salim Muhammad. 2017. Effects of lycopene on paraoxonase and adipokines parameters in streptozotocin-induced diabetic rabbits. Journal of Science and Technology : in Natural and Medical Sciences،Vol. 18, no. 1, pp.1-8.
https://search.emarefa.net/detail/BIM-834370
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Sarhat, Intizar Rifat& Said, Husam al-Din Salim Muhammad. Effects of lycopene on paraoxonase and adipokines parameters in streptozotocin-induced diabetic rabbits. Journal of Science and Technology : in Natural and Medical Sciences Vol. 18, no. 1 (Jun. 2017), pp.1-8.
https://search.emarefa.net/detail/BIM-834370
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Sarhat, Intizar Rifat& Said, Husam al-Din Salim Muhammad. Effects of lycopene on paraoxonase and adipokines parameters in streptozotocin-induced diabetic rabbits. Journal of Science and Technology : in Natural and Medical Sciences. 2017. Vol. 18, no. 1, pp.1-8.
https://search.emarefa.net/detail/BIM-834370
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 7-8
رقم السجل
BIM-834370
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر