Effects of lycopene on paraoxonase and adipokines parameters in streptozotocin-induced diabetic rabbits
Joint Authors
Said, Husam al-Din Salim Muhammad
Sarhat, Intizar Rifat
Source
Journal of Science and Technology : in Natural and Medical Sciences
Issue
Vol. 18, Issue 1 (30 Jun. 2017), pp.1-8, 8 p.
Publisher
Sudan University of Science and Technology Deanship of Scientific Research
Publication Date
2017-06-30
Country of Publication
Sudan
No. of Pages
8
Main Subjects
Abstract EN
Background: Diabetes mellitus (DM) is a metabolic disease characterized by hyperglycaemia resulting from defects in insulin secretion, insulin action, or both, and occurs in almost all populations of the world a variable prevalence.
Objectives: The current study assessed the impact of lycopene on adipokines and paraoxonase (PON) in stereptozotocin-induced diabetic rabbits.
Materials and Methods: A total of one hundred of rabbits (Albino Rabbits) of both sexes weighing between 1.5-2.1 kg were completely randomized in four groups (G) comprising 25 rabbits each.
Diabetes was induced by a single intraperitoneal injection of streptozotocin (35 mg/kg body weight) feeding on a high fat regimen.
Rabbits in G 3,4 which were administered 10 and 20 mg/kg respectively of lycopene for 4 weeks.
The serum levels of leptin, adiponectin, ghrelin, resistin, and tumour necrosis factor – α (TNF-α) were measured by enzyme-linked immunosorbent assay (ELISA), while serum PON was measured by spectrophotometric method.
SPSS computer software was used for data analysis.
Results:Results showed that lycopene administration at both doses significantly reduced the leptin, resistin, TNF-α, and glucose levels compared to diabetic control groupG2.
Consistent significant increases (p < 0.05) were noticed in the level of paraoxonase, adiponectin, and ghrelin in diabetic rabbits dealt with lycopene in comparison with diabetic rabbits of control group G2.
Conclusions: The high leptin, resistin, and TNF-α levels and oxidative damage whereas low linked with diabetes, were improved with the administration of lycopene.
American Psychological Association (APA)
Sarhat, Intizar Rifat& Said, Husam al-Din Salim Muhammad. 2017. Effects of lycopene on paraoxonase and adipokines parameters in streptozotocin-induced diabetic rabbits. Journal of Science and Technology : in Natural and Medical Sciences،Vol. 18, no. 1, pp.1-8.
https://search.emarefa.net/detail/BIM-834370
Modern Language Association (MLA)
Sarhat, Intizar Rifat& Said, Husam al-Din Salim Muhammad. Effects of lycopene on paraoxonase and adipokines parameters in streptozotocin-induced diabetic rabbits. Journal of Science and Technology : in Natural and Medical Sciences Vol. 18, no. 1 (Jun. 2017), pp.1-8.
https://search.emarefa.net/detail/BIM-834370
American Medical Association (AMA)
Sarhat, Intizar Rifat& Said, Husam al-Din Salim Muhammad. Effects of lycopene on paraoxonase and adipokines parameters in streptozotocin-induced diabetic rabbits. Journal of Science and Technology : in Natural and Medical Sciences. 2017. Vol. 18, no. 1, pp.1-8.
https://search.emarefa.net/detail/BIM-834370
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 7-8
Record ID
BIM-834370