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Association of proinflammatory cytokine IL-20 gene polymorphism with psoriasis in north Indian population
المؤلفون المشاركون
Wani, Aadil
Ganai, Bashir Ahmad
Akhtar, Tahsinah
Narang, Tarun
Kaur, Rajinder
المصدر
The Egyptian Journal of Medical Human Genetics
العدد
المجلد 19، العدد 3 (31 يوليو/تموز 2018)، ص ص. 201-205، 5ص.
الناشر
الجمعية المصرية للأمراض الوراثية
تاريخ النشر
2018-07-31
دولة النشر
مصر
عدد الصفحات
5
التخصصات الرئيسية
الملخص EN
Background: IL-20 plays an important role in the inflammatory and hyperproliferative dermatosis of psoriasis.
Aim: The aim of the study was to determine whether the IL-20 gene polymorphism, haplotype and serum level confer pathogenesis of psoriasis.
Subjects and methods: 200 psoriatic patients and 200 controls were genotyped for four IL-20 polymorphic sites by polymerase chain reaction.
Serum levels of IL-20 were measured by ELISA.
Results: Our results demonstrated that polymorphism of IL-120 1380 A/G (adjusted⁄ OR 5.52; (95% CI = 2.43–12.55) was found to be in association with increased risk of psoriasis while as IL-20–1462 G/A (adjusted⁄ OR = 0.11 95; (95% CI = 0.03–0.34) was found to be in association with decreased risk of psoriasis and IL-20–1053 G/T adjusted⁄ OR 1.99; (95% CI = 0.86–4.64), IL-20–3978 T/C(adjusted⁄ OR = 12.87; (95% CI = 0.97–79.54) polymorphism does not show any significant association with the risk of psoriasis.
HT4 TG haplotype is associated with decreased risk of psoriasis.
Serum IL-20 level significantly increases in patients, as compared to controls with non-significant correlation between serum IL-20 and psoriasis severity.
Conclusion: These findings suggest that IL-20 polymorphism have significant role towards the susceptibility of psoriasis in north Indian population.
Evaluating the role of IL-20 cytokine in pathogenesis of psoriasis will prove helpful for the development of psoriasis management.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Wani, Aadil& Ganai, Bashir Ahmad& Akhtar, Tahsinah& Narang, Tarun& Kaur, Rajinder. 2018. Association of proinflammatory cytokine IL-20 gene polymorphism with psoriasis in north Indian population. The Egyptian Journal of Medical Human Genetics،Vol. 19, no. 3, pp.201-205.
https://search.emarefa.net/detail/BIM-836351
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Wani, Aadil…[et al.]. Association of proinflammatory cytokine IL-20 gene polymorphism with psoriasis in north Indian population. The Egyptian Journal of Medical Human Genetics Vol. 19, no. 3 (Jul. 2018), pp.201-205.
https://search.emarefa.net/detail/BIM-836351
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Wani, Aadil& Ganai, Bashir Ahmad& Akhtar, Tahsinah& Narang, Tarun& Kaur, Rajinder. Association of proinflammatory cytokine IL-20 gene polymorphism with psoriasis in north Indian population. The Egyptian Journal of Medical Human Genetics. 2018. Vol. 19, no. 3, pp.201-205.
https://search.emarefa.net/detail/BIM-836351
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 205
رقم السجل
BIM-836351
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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