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Association of proinflammatory cytokine IL-20 gene polymorphism with psoriasis in north Indian population
Joint Authors
Wani, Aadil
Ganai, Bashir Ahmad
Akhtar, Tahsinah
Narang, Tarun
Kaur, Rajinder
Source
The Egyptian Journal of Medical Human Genetics
Issue
Vol. 19, Issue 3 (31 Jul. 2018), pp.201-205, 5 p.
Publisher
Egyptian Society of Human Genetics
Publication Date
2018-07-31
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Background: IL-20 plays an important role in the inflammatory and hyperproliferative dermatosis of psoriasis.
Aim: The aim of the study was to determine whether the IL-20 gene polymorphism, haplotype and serum level confer pathogenesis of psoriasis.
Subjects and methods: 200 psoriatic patients and 200 controls were genotyped for four IL-20 polymorphic sites by polymerase chain reaction.
Serum levels of IL-20 were measured by ELISA.
Results: Our results demonstrated that polymorphism of IL-120 1380 A/G (adjusted⁄ OR 5.52; (95% CI = 2.43–12.55) was found to be in association with increased risk of psoriasis while as IL-20–1462 G/A (adjusted⁄ OR = 0.11 95; (95% CI = 0.03–0.34) was found to be in association with decreased risk of psoriasis and IL-20–1053 G/T adjusted⁄ OR 1.99; (95% CI = 0.86–4.64), IL-20–3978 T/C(adjusted⁄ OR = 12.87; (95% CI = 0.97–79.54) polymorphism does not show any significant association with the risk of psoriasis.
HT4 TG haplotype is associated with decreased risk of psoriasis.
Serum IL-20 level significantly increases in patients, as compared to controls with non-significant correlation between serum IL-20 and psoriasis severity.
Conclusion: These findings suggest that IL-20 polymorphism have significant role towards the susceptibility of psoriasis in north Indian population.
Evaluating the role of IL-20 cytokine in pathogenesis of psoriasis will prove helpful for the development of psoriasis management.
American Psychological Association (APA)
Wani, Aadil& Ganai, Bashir Ahmad& Akhtar, Tahsinah& Narang, Tarun& Kaur, Rajinder. 2018. Association of proinflammatory cytokine IL-20 gene polymorphism with psoriasis in north Indian population. The Egyptian Journal of Medical Human Genetics،Vol. 19, no. 3, pp.201-205.
https://search.emarefa.net/detail/BIM-836351
Modern Language Association (MLA)
Wani, Aadil…[et al.]. Association of proinflammatory cytokine IL-20 gene polymorphism with psoriasis in north Indian population. The Egyptian Journal of Medical Human Genetics Vol. 19, no. 3 (Jul. 2018), pp.201-205.
https://search.emarefa.net/detail/BIM-836351
American Medical Association (AMA)
Wani, Aadil& Ganai, Bashir Ahmad& Akhtar, Tahsinah& Narang, Tarun& Kaur, Rajinder. Association of proinflammatory cytokine IL-20 gene polymorphism with psoriasis in north Indian population. The Egyptian Journal of Medical Human Genetics. 2018. Vol. 19, no. 3, pp.201-205.
https://search.emarefa.net/detail/BIM-836351
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 205
Record ID
BIM-836351