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Genotyping of PPAR-c gene polymorphism in Egyptian neonates affected with sepsis disease and its severity
المؤلفون المشاركون
Shawqi, Rabah M.
Kamal, Tariq M.
Rafat, Shayma Muhammad
al-Nadi, Ghadah H.
المصدر
The Egyptian Journal of Medical Human Genetics
العدد
المجلد 19، العدد 3 (31 يوليو/تموز 2018)، ص ص. 215-220، 6ص.
الناشر
الجمعية المصرية للأمراض الوراثية
تاريخ النشر
2018-07-31
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
Background : Peroxisome Proliferator-Activated Receptor gamma (PPARc) is a ligand-dependent transcription factor involved in inflammatory process.
PPAR-c gene was mentioned as having a modulating role in the pathological status of sepsis.
The present study aimed to make a correlation between The Pro12Ala polymorphism in PPAR-c gene and occurrence of neonatal sepsis and its severity among a sample of Egyptian neonates suffering sepsis.
Subjects and methods: This case-control study included 30 neonates (11 females and19 males) newly admitted with neonatal sepsis at the intensive care unit (NICU) (mean age 10.3 days ± 6.23).
The control group included 50 age and sex matched neonates (23 females and 27 males) (mean age 10.20 days ± 5.36 days).
All the neonates (preterm and full term) included were with clinical signs and laboratory data consistent with neonatal sepsis.
Genotyping for PPARc gene region harboring the Pro12Ala variant locus were carried out using Tetra ARMS technique.
Results: About 56.7% of the patients group was homozygote (GG) for polymorphic locus (coding for Alanine/Alanine) while 30% was heterozygote for polymorphic locus (CG) (coding for Proline/Alanine) and up to 13.3% was homozygote for the polymorphic locus (CC) (coding for Proline/Proline).
Compared to the control group where homozygotes for CC were the most prevalent (90%) and the CG were 10% with absence of GG genotypes.
There was a strong statistical significant difference between patients and the normal control group as regards prevalence of PPAR-c gene polymorphism in occurrence of neonatal sepsis and its severity.
Also, there were strong relation between genotype GG and low birth weight, neonatal fever, prematurity and depressed neonatal reflexes.
Conclusion: PPAR-c gene has been suggested to be a candidate gene for neonatal sepsis.
Therefore, Pro12Ala polymorphism might be useful in predicting the risk factor of neonatal sepsis and its severity.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Shawqi, Rabah M.& Kamal, Tariq M.& Rafat, Shayma Muhammad& al-Nadi, Ghadah H.. 2018. Genotyping of PPAR-c gene polymorphism in Egyptian neonates affected with sepsis disease and its severity. The Egyptian Journal of Medical Human Genetics،Vol. 19, no. 3, pp.215-220.
https://search.emarefa.net/detail/BIM-836374
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Shawqi, Rabah M.…[et al.]. Genotyping of PPAR-c gene polymorphism in Egyptian neonates affected with sepsis disease and its severity. The Egyptian Journal of Medical Human Genetics Vol. 19, no. 3 (Jul. 2018), pp.215-220.
https://search.emarefa.net/detail/BIM-836374
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Shawqi, Rabah M.& Kamal, Tariq M.& Rafat, Shayma Muhammad& al-Nadi, Ghadah H.. Genotyping of PPAR-c gene polymorphism in Egyptian neonates affected with sepsis disease and its severity. The Egyptian Journal of Medical Human Genetics. 2018. Vol. 19, no. 3, pp.215-220.
https://search.emarefa.net/detail/BIM-836374
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 219-220
رقم السجل
BIM-836374
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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