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Genotyping of PPAR-c gene polymorphism in Egyptian neonates affected with sepsis disease and its severity
Joint Authors
Shawqi, Rabah M.
Kamal, Tariq M.
Rafat, Shayma Muhammad
al-Nadi, Ghadah H.
Source
The Egyptian Journal of Medical Human Genetics
Issue
Vol. 19, Issue 3 (31 Jul. 2018), pp.215-220, 6 p.
Publisher
Egyptian Society of Human Genetics
Publication Date
2018-07-31
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Background : Peroxisome Proliferator-Activated Receptor gamma (PPARc) is a ligand-dependent transcription factor involved in inflammatory process.
PPAR-c gene was mentioned as having a modulating role in the pathological status of sepsis.
The present study aimed to make a correlation between The Pro12Ala polymorphism in PPAR-c gene and occurrence of neonatal sepsis and its severity among a sample of Egyptian neonates suffering sepsis.
Subjects and methods: This case-control study included 30 neonates (11 females and19 males) newly admitted with neonatal sepsis at the intensive care unit (NICU) (mean age 10.3 days ± 6.23).
The control group included 50 age and sex matched neonates (23 females and 27 males) (mean age 10.20 days ± 5.36 days).
All the neonates (preterm and full term) included were with clinical signs and laboratory data consistent with neonatal sepsis.
Genotyping for PPARc gene region harboring the Pro12Ala variant locus were carried out using Tetra ARMS technique.
Results: About 56.7% of the patients group was homozygote (GG) for polymorphic locus (coding for Alanine/Alanine) while 30% was heterozygote for polymorphic locus (CG) (coding for Proline/Alanine) and up to 13.3% was homozygote for the polymorphic locus (CC) (coding for Proline/Proline).
Compared to the control group where homozygotes for CC were the most prevalent (90%) and the CG were 10% with absence of GG genotypes.
There was a strong statistical significant difference between patients and the normal control group as regards prevalence of PPAR-c gene polymorphism in occurrence of neonatal sepsis and its severity.
Also, there were strong relation between genotype GG and low birth weight, neonatal fever, prematurity and depressed neonatal reflexes.
Conclusion: PPAR-c gene has been suggested to be a candidate gene for neonatal sepsis.
Therefore, Pro12Ala polymorphism might be useful in predicting the risk factor of neonatal sepsis and its severity.
American Psychological Association (APA)
Shawqi, Rabah M.& Kamal, Tariq M.& Rafat, Shayma Muhammad& al-Nadi, Ghadah H.. 2018. Genotyping of PPAR-c gene polymorphism in Egyptian neonates affected with sepsis disease and its severity. The Egyptian Journal of Medical Human Genetics،Vol. 19, no. 3, pp.215-220.
https://search.emarefa.net/detail/BIM-836374
Modern Language Association (MLA)
Shawqi, Rabah M.…[et al.]. Genotyping of PPAR-c gene polymorphism in Egyptian neonates affected with sepsis disease and its severity. The Egyptian Journal of Medical Human Genetics Vol. 19, no. 3 (Jul. 2018), pp.215-220.
https://search.emarefa.net/detail/BIM-836374
American Medical Association (AMA)
Shawqi, Rabah M.& Kamal, Tariq M.& Rafat, Shayma Muhammad& al-Nadi, Ghadah H.. Genotyping of PPAR-c gene polymorphism in Egyptian neonates affected with sepsis disease and its severity. The Egyptian Journal of Medical Human Genetics. 2018. Vol. 19, no. 3, pp.215-220.
https://search.emarefa.net/detail/BIM-836374
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 219-220
Record ID
BIM-836374