Association of P2X7 gene common polymorphisms with pulmonary tuberculosis in Lur population of Iran
المؤلفون المشاركون
Azargoon, Alireza
Ahmadi, Sayyid Amir Yasin
Amiri, Ali
Sabutih, Tumaj
Shahsavar, Farhad
المصدر
The Egyptian Journal of Medical Human Genetics
العدد
المجلد 19، العدد 3 (31 يوليو/تموز 2018)، ص ص. 231-234، 4ص.
الناشر
الجمعية المصرية للأمراض الوراثية
تاريخ النشر
2018-07-31
دولة النشر
مصر
عدد الصفحات
4
التخصصات الرئيسية
الملخص EN
Background: Different genetic and environmental factors are associated with susceptibility to pulmonary tuberculosis (TB) in different individuals of different populations.
Based on previous studies role of P2X7 gene common polymorphisms in susceptibility to pulmonary TB was associated with ethnicities.
Aim: We intend to perform this study on genetic reservoir (gene pool) of Lur population of western Iran.
Methods : For the present case-control study, 100 unrelated pulmonary TB patients and 100 unrelated controls were enrolled through convenient sampling.
TB confirmation was through smear and culture of sputum.
Polymerase chain reaction with restriction fragment length polymorphism (PCR-RFLP) was used for molecular assay.
This study has been approved in the ethic committee of Lorestan University of Medical Sciences with registration number LUMS.REC.1396.253.
Results: Among the genotypes of polymorphism 1513A/C, AA genotype was associated with susceptibility to pulmonary TB (P = .0001; OR = 4.750) whereas AC genotype was a protecting factor (P = .0001; OR = 0.192).
Higher genetic reservoir of A allele was associated with more susceptibility to pulmonary TB (P = .0001; OR = 2.879) whereas C allele was a protecting factor (P = .0001; OR = 0.347).
No significant result was found for 762T/C polymorphism.
Conclusion: In Lur population of Iran, 1513A/C polymorphism of P2X7 is associated with susceptibility to pulmonary TB.
It is suggested that bio-information banks should be established and developed in countries.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Amiri, Ali& Sabutih, Tumaj& Ahmadi, Sayyid Amir Yasin& Azargoon, Alireza& Shahsavar, Farhad. 2018. Association of P2X7 gene common polymorphisms with pulmonary tuberculosis in Lur population of Iran. The Egyptian Journal of Medical Human Genetics،Vol. 19, no. 3, pp.231-234.
https://search.emarefa.net/detail/BIM-836505
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Amiri, Ali…[et al.]. Association of P2X7 gene common polymorphisms with pulmonary tuberculosis in Lur population of Iran. The Egyptian Journal of Medical Human Genetics Vol. 19, no. 3 (Jul. 2018), pp.231-234.
https://search.emarefa.net/detail/BIM-836505
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Amiri, Ali& Sabutih, Tumaj& Ahmadi, Sayyid Amir Yasin& Azargoon, Alireza& Shahsavar, Farhad. Association of P2X7 gene common polymorphisms with pulmonary tuberculosis in Lur population of Iran. The Egyptian Journal of Medical Human Genetics. 2018. Vol. 19, no. 3, pp.231-234.
https://search.emarefa.net/detail/BIM-836505
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 234
رقم السجل
BIM-836505
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر