Association of P2X7 gene common polymorphisms with pulmonary tuberculosis in Lur population of Iran
Joint Authors
Azargoon, Alireza
Ahmadi, Sayyid Amir Yasin
Amiri, Ali
Sabutih, Tumaj
Shahsavar, Farhad
Source
The Egyptian Journal of Medical Human Genetics
Issue
Vol. 19, Issue 3 (31 Jul. 2018), pp.231-234, 4 p.
Publisher
Egyptian Society of Human Genetics
Publication Date
2018-07-31
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Abstract EN
Background: Different genetic and environmental factors are associated with susceptibility to pulmonary tuberculosis (TB) in different individuals of different populations.
Based on previous studies role of P2X7 gene common polymorphisms in susceptibility to pulmonary TB was associated with ethnicities.
Aim: We intend to perform this study on genetic reservoir (gene pool) of Lur population of western Iran.
Methods : For the present case-control study, 100 unrelated pulmonary TB patients and 100 unrelated controls were enrolled through convenient sampling.
TB confirmation was through smear and culture of sputum.
Polymerase chain reaction with restriction fragment length polymorphism (PCR-RFLP) was used for molecular assay.
This study has been approved in the ethic committee of Lorestan University of Medical Sciences with registration number LUMS.REC.1396.253.
Results: Among the genotypes of polymorphism 1513A/C, AA genotype was associated with susceptibility to pulmonary TB (P = .0001; OR = 4.750) whereas AC genotype was a protecting factor (P = .0001; OR = 0.192).
Higher genetic reservoir of A allele was associated with more susceptibility to pulmonary TB (P = .0001; OR = 2.879) whereas C allele was a protecting factor (P = .0001; OR = 0.347).
No significant result was found for 762T/C polymorphism.
Conclusion: In Lur population of Iran, 1513A/C polymorphism of P2X7 is associated with susceptibility to pulmonary TB.
It is suggested that bio-information banks should be established and developed in countries.
American Psychological Association (APA)
Amiri, Ali& Sabutih, Tumaj& Ahmadi, Sayyid Amir Yasin& Azargoon, Alireza& Shahsavar, Farhad. 2018. Association of P2X7 gene common polymorphisms with pulmonary tuberculosis in Lur population of Iran. The Egyptian Journal of Medical Human Genetics،Vol. 19, no. 3, pp.231-234.
https://search.emarefa.net/detail/BIM-836505
Modern Language Association (MLA)
Amiri, Ali…[et al.]. Association of P2X7 gene common polymorphisms with pulmonary tuberculosis in Lur population of Iran. The Egyptian Journal of Medical Human Genetics Vol. 19, no. 3 (Jul. 2018), pp.231-234.
https://search.emarefa.net/detail/BIM-836505
American Medical Association (AMA)
Amiri, Ali& Sabutih, Tumaj& Ahmadi, Sayyid Amir Yasin& Azargoon, Alireza& Shahsavar, Farhad. Association of P2X7 gene common polymorphisms with pulmonary tuberculosis in Lur population of Iran. The Egyptian Journal of Medical Human Genetics. 2018. Vol. 19, no. 3, pp.231-234.
https://search.emarefa.net/detail/BIM-836505
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 234
Record ID
BIM-836505